2. Apoptosis
  3. Apoptosis
  4. Sodium diatrizoate

Sodium diatrizoate  (Synonyms: Diatrizoic acid sodium salt; Sodium amidotrizoate)

Cat. No.: HY-B0926A Purity: 99.50%
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Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium.

For research use only. We do not sell to patients.

Sodium diatrizoate Chemical Structure

Sodium diatrizoate Chemical Structure

CAS No. : 737-31-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Sodium diatrizoate:

Sodium diatrizoate Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium[1][2].

In Vitro

HK-2 cells are exposed to 0-30 mg I/mL Sodium diatrizoate (Diatrizoic acid sodium salt) or vehicle for 2-24 h. MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium diatrizoate Related Antibodies
In Vivo

Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium diatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

635.90

Formula

C11H8I3N2NaO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (157.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (78.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5726 mL 7.8629 mL 15.7257 mL
5 mM 0.3145 mL 1.5726 mL 3.1451 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (52.41 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Animal Administration
[1]

Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Sodium diatrizoate nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.5726 mL 7.8629 mL 15.7257 mL 39.3144 mL
5 mM 0.3145 mL 1.5726 mL 3.1451 mL 7.8629 mL
10 mM 0.1573 mL 0.7863 mL 1.5726 mL 3.9314 mL
15 mM 0.1048 mL 0.5242 mL 1.0484 mL 2.6210 mL
20 mM 0.0786 mL 0.3931 mL 0.7863 mL 1.9657 mL
25 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5726 mL
30 mM 0.0524 mL 0.2621 mL 0.5242 mL 1.3105 mL
40 mM 0.0393 mL 0.1966 mL 0.3931 mL 0.9829 mL
50 mM 0.0315 mL 0.1573 mL 0.3145 mL 0.7863 mL
60 mM 0.0262 mL 0.1310 mL 0.2621 mL 0.6552 mL
DMSO 80 mM 0.0197 mL 0.0983 mL 0.1966 mL 0.4914 mL
100 mM 0.0157 mL 0.0786 mL 0.1573 mL 0.3931 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium diatrizoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium diatrizoate737-31-5Diatrizoic acid Sodium amidotrizoateApoptosisInhibitorinhibitorinhibit

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