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  3. Solutol HS-15

Solutol HS-15  (Synonyms: Polyethylene glycol 12-hydroxystearate)

Cat. No.: HY-Y1893
COA Handling Instructions

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.

For research use only. We do not sell to patients.

Solutol HS-15 Chemical Structure

Solutol HS-15 Chemical Structure

CAS No. : 61909-81-7

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Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer[1].

In Vitro

Solutol HS-15 is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Solutol HS-15 has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

(C2H4O)nC18H36O3

CAS No.
Appearance

Oil

Color

White to light yellow

SMILES

CCCCCCC(O)CCCCCCCCCCC(OCCO)=O.[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (Need ultrasonic)

H2O : 25 mg/mL (Need ultrasonic)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

References
Cell Assay
[1]

For both MTS and LDH cell viability assays, cells are seeded at a density of 1×104 cells on 96-well plates and cultured for a minimum of 24 h. Solutol HS-15 (in 25 mM HBSS:HEPES, pH 7.4) solutions are applied at concentrations above and below the critical micelle concentration (CMC) (0.01 mM to 20 mM) and cytotoxicity is determined using the MTS and LDH assays. 25 mM HBSS:HEPES is used as a negative control and Triton-X 100 (3 mM) as a positive control. Following 3 h incubation, the MTS reagent in media and LDH working solution are added to the cells and the cells are incubated for a further 3 h at 37°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Solutol HS-15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Solutol HS-15
Cat. No.:
HY-Y1893
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