2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. SuO-Val-Cit-PAB-MMAE

SuO-Val-Cit-PAB-MMAE est un conjugué de liaison médicamenteuse pour l'ADC en utilisant l'agent antimitotique, la monométhylauristatine E (MMAE, un inhibiteur de la tubuline), lié via le peptide SuO-Val -Cit-PAB.

SuO-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the peptide SuO-Val-Cit-PAB.

For research use only. We do not sell to patients.

SuO-Val-Cit-PAB-MMAE Chemical Structure

SuO-Val-Cit-PAB-MMAE Chemical Structure

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5 mg USD 310 In-stock
10 mg USD 500 In-stock
50 mg USD 1480 In-stock
100 mg USD 2380 In-stock
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Based on 1 publication(s) in Google Scholar

SuO-Val-Cit-PAB-MMAE Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SuO-Val-Cit-PAB-MMAE

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SuO-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the peptide SuO-Val-Cit-PAB[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SuO-Val-Cit-PAB-MMAE Related Antibodies
Molecular Weight

1264.51

Formula

C63H97N11O16
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(ON4C(CCC4=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C
Shipping

Shipping with dry ice.
Storage

-80°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (7.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7908 mL 3.9541 mL 7.9082 mL
5 mM 0.1582 mL 0.7908 mL 1.5816 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

COA (254 KB) HNMR (161 KB) RP-HPLC (210 KB) MS (70 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7908 mL 3.9541 mL 7.9082 mL 19.7705 mL
5 mM 0.1582 mL 0.7908 mL 1.5816 mL 3.9541 mL
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SuO-Val-Cit-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SuO-Val-Cit-PAB-MMAEDrug-Linker Conjugates for ADCdrug-linkerconjugateADCSuO-Val-Cit-PABmonomethylauristatinEMMAEtubulinInhibitorinhibitorinhibit

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HY-100566
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