2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Anti-infection Apoptosis
  3. Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis
  4. Suramin sodium salt

Suramin sodium salt  (Synonyms: Suramin hexasodium salt)

Cat. No.: HY-B0879A Purity: 99.48%
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Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

For research use only. We do not sell to patients.

Suramin sodium salt Chemical Structure

Suramin sodium salt Chemical Structure

CAS No. : 129-46-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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50 mg USD 480 In-stock
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Based on 14 publication(s) in Google Scholar

Other Forms of Suramin sodium salt:

Suramin sodium salt Related Antibodies

Top Publications Citing Use of Products

    Suramin sodium salt purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2020 Jul 24;295(30):10281-10292.  [Abstract]

    Suramin inhibits IP5K function in vivo. Immunoprecipitation of myc-CSN2 from myc-CSN2-HEK293 stable cell after IP5K knockdown, with or without Suramin or NF449 treatment.

    View All Sirtuin Isoform Specific Products:

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    Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

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    Topoisomerase Topo I Topo II

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    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    • Biological Activity

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    • References

    • Customer Review

    Description

    Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5]. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].

    IC50 & Target[2]

    SIRT1

    297 nM (IC50)

    SIRT2

    1.15 μM (IC50)

    SIRT5

    22 μM (IC50)

    In Vitro

    Suramin sodium salt (Suramin hexasodium salt; 50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells[7].
    Suramin sodium salt (300 μg/mL; for 48 hours) induces cells apoptosis and down-regulates mRNA expression in HeLa cells[7].
    Suramin sodium salt (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2[8].
    The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively[7].
    Suramin blocks viral replication in Vero E6 cells[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Suramin sodium salt Related Antibodies

    Cell Proliferation Assay[6]

    Cell Line: HO-8910 PM ovarian and Hela cervical cancer cells
    Concentration: 50, 100, 200, 300, 400, 500 and 600 μg/mL
    Incubation Time: For 24, 48, 72 and 96 hours
    Result: Inhibited cells proliferation in a dose-dependent and time-dependent manner.

    Apoptosis Analysis[6]

    Cell Line: HeLa cells
    Concentration: 300 μg/mL
    Incubation Time: For 48 hours
    Result: Induced cells apoptosis.

    Western Blot Analysis[7]

    Cell Line: PA-SMCs cells
    Concentration: 1 mg/mL
    Incubation Time: For 1 hour
    Result: Significantly suppressed the phosphorylated ERK1/2.
    In Vivo

    Suramin sodium salt (Suramin hexasodium salt; 10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure[8].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Wistar rats (200-225 g)[7]
    Dosage: 10 mg/kg
    Administration: IV; twice weekly for 3 weeks
    Result: Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.
    Clinical Trial
    Molecular Weight

    1429.17

    Formula

    C51H34N6Na6O23S6
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light brown

    SMILES

    O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6C)=O)=CC=C5
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 83.33 mg/mL (58.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (34.99 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6997 mL 3.4985 mL 6.9971 mL
    5 mM 0.1399 mL 0.6997 mL 1.3994 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (1.46 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (1.46 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (69.97 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.48%

    COA (248 KB) HNMR (366 KB) LCMS (268 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.6997 mL 3.4985 mL 6.9971 mL 17.4927 mL
    5 mM 0.1399 mL 0.6997 mL 1.3994 mL 3.4985 mL
    10 mM 0.0700 mL 0.3499 mL 0.6997 mL 1.7493 mL
    15 mM 0.0466 mL 0.2332 mL 0.4665 mL 1.1662 mL
    20 mM 0.0350 mL 0.1749 mL 0.3499 mL 0.8746 mL
    25 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6997 mL
    30 mM 0.0233 mL 0.1166 mL 0.2332 mL 0.5831 mL
    DMSO 40 mM 0.0175 mL 0.0875 mL 0.1749 mL 0.4373 mL
    50 mM 0.0140 mL 0.0700 mL 0.1399 mL 0.3499 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Suramin sodium salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Suramin129-46-4Suramin hexasodiumPhosphataseSirtuinReverse TranscriptaseTopoisomeraseSARS-CoVParasiteApoptosisSARS coronavirusprotein-tyrosinephosphatasesPTPasesDNAtopoisomeraseIIantitrypanosomalanti-neoplasticanti-angiogenicIP5KantiparasiticInhibitorinhibitorinhibit

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