1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

TMC647055 Choline salt 

Cat. No.: HY-15591A
Handling Instructions

TMC647055 choline salt is a cell-permeating, selective HCV NS5B inhibitor, eliciting a mean IC50 of 34 nM, as assessed in the RdRp primer-dependent transcription assay.

For research use only. We do not sell to patients.
TMC647055 Choline salt Chemical Structure

TMC647055 Choline salt Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO $480 In-stock
5 mg $300 In-stock
10 mg $450 In-stock
50 mg $1300 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

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Description

TMC647055 choline salt is a cell-permeating, selective HCV NS5B inhibitor, eliciting a mean IC50 of 34 nM, as assessed in the RdRp primer-dependent transcription assay. IC50 value: 34 nM [1] Target: HCV NS5B in vitro: TMC647055 is a novel and potent nonnucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase. TMC647055 shows high selectivity for HCV when evaluated with a broad panel of human DNA and RNA viruses. TMC647055 shows median EC50 changes in the replicon assay of 9-, 3-, and 371-fold for L392I, V494A, and P495L, respectively, The median EC50 of TMC647055 on NS5B sequences derived from clinical isolates of genotypes 1a, 1b, 3a, 4a, and 6a ranged between 27 nM and 113 nM.[1]

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.3738 mL 6.8690 mL 13.7380 mL
5 mM 0.2748 mL 1.3738 mL 2.7476 mL
10 mM 0.1374 mL 0.6869 mL 1.3738 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

727.91

Formula

C₃₇H₅₃N₅O₈S

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 43 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
TMC647055 Choline salt
Cat. No.:
HY-15591A
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