2. PROTAC Epigenetics
  3. Ligands for Target Protein for PROTAC Epigenetic Reader Domain
  4. I-BET762 carboxylic acid

I-BET762 carboxylic acid  (Synonyms: Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2)

Cat. No.: HY-107443 Purity: 98.64%
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I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.

For research use only. We do not sell to patients.

I-BET762 carboxylic acid Chemical Structure

I-BET762 carboxylic acid Chemical Structure

CAS No. : 1300019-38-8

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Based on 1 publication(s) in Google Scholar

Other Forms of I-BET762 carboxylic acid:

I-BET762 carboxylic acid Related Antibodies

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Description

I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1[1].

IC50 & Target

BRD4

5.1 (pIC50)

In Vitro

I-BET762 carboxylic acid (Molibresib carboxylic acid) (Compound 27) inhibits peripheral blood mononuclear cells (PBMC) with a pIC50 of <4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

I-BET762 carboxylic acid Related Antibodies
Molecular Weight

396.83

Formula

C20H17ClN4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=NN=C2[C@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 7.14 mg/mL (17.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5200 mL 12.5999 mL 25.1997 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5200 mL 12.5999 mL 25.1997 mL 62.9993 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL 12.5999 mL
10 mM 0.2520 mL 1.2600 mL 2.5200 mL 6.2999 mL
15 mM 0.1680 mL 0.8400 mL 1.6800 mL 4.2000 mL
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I-BET762 carboxylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I-BET762 carboxylic acid1300019-38-8Molibresib carboxylic acid GSK525762A carboxylic acid PROTAC BRD4-binding moiety 2Ligands for Target Protein for PROTACEpigenetic Reader DomainTarget Protein-binding MoietyInhibitorinhibitorinhibit

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