1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker

ADC Linker

Antibody-drug conjugates (ADCs) are a new class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer. ADCs are complex molecules composed of an antibody, a linker and a biological active cytotoxic. ADCs linkers are based on chemical motifs including disulfides, hydrazones or peptides (cleavable), or thioethers (noncleavable) and control the distribution and delivery of the cytotoxic agent to the target cell. Cleavable and noncleavable types of linkers have been proven to be safe in preclinical and clinical trials. A stable link between the antibody and cytotoxic (anti-cancer) agent is a crucial aspect of an ADC.

ADC Linker Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-20336
    Mc-Val-Cit-PABC-PNP
    Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker.
  • HY-78738
    MC-Val-Cit-PAB 99.56%
    MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate.
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP
    Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).
  • HY-12362
    Val-cit-PAB-OH 99.35%
    Val-cit-PAB-OH is a peptide prodrug linker.
  • HY-21210
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- is an useful linker for antibody-drug-conjugations (ADCs), extracted from [Bioorg Chem. 2012 Apr-Jun;41-42:1-5.] compound 1i.
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester 99.96%
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates.
  • HY-19318
    Fmoc-Val-Cit-PAB
    Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).
  • HY-20560
    (Ac)Phe-Lys(Alloc)-PABC-PNP
    (Ac)Phe-Lys(Alloc)-PABC-PNP is a useful chemical linker in antibody drug conjugates.