1. GPCR/G Protein
  2. Adenylate Cyclase

Adenylate Cyclase

cAMP is produced by adenylatecyclase (AC), a 12-transmembrane-spanning enzyme that catalyzes the conversion of ATP to 3′,5′-cAMP and pyrophosphate.

In neuronal and neuroendocrine cells, a variety of ligands, such as neurotransmitters and hormones, signal via activation of G protein coupled receptors (GPCRs) coupled to GSα. These receptors activate adenylatecyclases (ACs), the family of enzymes that generate cAMP.

cAMP is synthesized by adenylatecyclases (ACs) and degraded by phosphodiesterases (PDEs). Local cAMP signaling is achieved by targeting of signaling components to subcellular compartments and assembly of signaling complexes. Primary cilia also host several cAMP-signaling components: the somatostatin 3 receptor (SSTR3), various adenylatecyclases (AC3, AC4, AC6, AC8), PKA, and Epac2 (exchange protein directly activated by cAMP).

Adenylate Cyclase Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-15371
    Forskolin Activator 98.60%
    Forskolin is a potent adenylate cyclase activator, with binding (IC50=41 nM) to and activation (EC50=0.5 μM) of type I adenylyl cyclase.
  • HY-100396
    SQ22536 Inhibitor 98.43%
    SQ22536 is an effective adenylate cyclase (AC) inhibitor.
  • HY-101279
    ST034307 Inhibitor
    ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
  • HY-101862
    CB-7921220 Inhibitor >98.0%
    CB-7921220 is an adenylate cyclase inhibitor.
  • HY-P0252
    α-Melanocyte-Stimulating Hormone (MSH), amide Activator
    α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.