1. GPCR/G Protein
  2. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Related Products (130):

Cat. No. Product Name Effect Purity
  • HY-13715B
    Norepinephrine bitartrate monohydrate Agonist
    Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
  • HY-B0468
    Isoprenaline hydrochloride Agonist
    Isoprenaline (hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
  • HY-13951
    ICI 118,551 hydrochloride Antagonist
    ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride Agonist
    (R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist Target: α1- Adrenergic Receptor Phenylephrine (PE), an alpha-adrenergic agonist and promoter of hypertrophic growth in the ventricular myocyte, to activate the three best-characterized mitogen-activated protein kinase (MAPK) subfamilies, namely p38-MAPKs, SAPKs/JNKs (i.
  • HY-B0573
    Propranolol hydrochloride Antagonist
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM.
  • HY-101416
    Vanilpyruvic acid
    Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
  • HY-14301
    Olodaterol Agonist
    Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.
  • HY-12980
    Batefenterol Agonist
    Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
  • HY-14300A
    Vilanterol trifenatate Agonist
    Vilanterol trifenatate is a long-acting β2-adrenoceptor2-AR) agonist with 24 h activity. The pEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.
  • HY-B0162A
    Ivabradine hydrochloride Inhibitor
    Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
  • HY-17453
    Salmeterol xinafoate Agonist
    Salmeterol(GR 33343X) xinafoate is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma and chronic obstructive pulmonary disease(COPD).
  • HY-B0431A
    Phenoxybenzamine hydrochloride Antagonist
    Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with long duration of action.
  • HY-B0447B
    L-Epinephrine Agonist
    L-Epinephrine(L-Adrenaline) is a hormone and a neurotransmitter.
  • HY-N0127
    Yohimbine Hydrochloride Antagonist
    Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
  • HY-12380
    Atipamezole hydrochloride Antagonist
    Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
  • HY-A0077
    Perphenazine Inhibitor
    Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor (5-HT2A), Alpha-1A adrenergic receptor (α1A), Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor (H1) with Ki of 5.6, 10, 0.765/0.13, 3.4, and 8 nM.
  • HY-14773
    Mirabegron Agonist
    Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
  • HY-B0362A
    Phentolamine mesylate Antagonist
    Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.
  • HY-B0409A
    Clonidine hydrochloride Agonist
    Clonidine Hydrochloride is a centrally acting alpha-agonist hypotensive agent.
  • HY-10122
    Silodosin Antagonist
    Silodosin (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonist with high uroselectivity; In treatment of dysuria.