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Androgen Receptor

Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).

Androgen Receptor Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-70002
    Enzalutamide Antagonist
    Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
  • HY-16060
    ARN-509 Antagonist
    ARN-509 is a potent and competitive androgen receptor (AR) antagonist, binds AR with IC50 of 16 nM.
  • HY-16985
    ODM-201 Antagonist
    ODM-201 is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in AR-HEK293 cells.
  • HY-14249
    Bicalutamide Agonist
    Bicalutamide(Casodex) is an oral non-steroidal anti-androgen for prostate cancer; binds to the androgen receptor.
  • HY-14650
    DHEA Inhibitor
    DHEA is an important source of androgens, and is an effective antiapoptotic factor.
  • HY-B1405
    Dehydroisoandrosterone 3-acetate Agonist
    Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.
  • HY-15194
    ASC-J9 Inhibitor
    ASC-J9 is antitumor agent, suppressesing castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors.
  • HY-15758
    3,3'-Diindolylmethane Antagonist
    3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
  • HY-11027
    MK-0773 Inhibitor
    MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.
  • HY-B1269
    Testosterone propionate Agonist
    Testosterone Propionate is an efficient androgenic hormone for the treatment of low testosterone.
  • HY-13981
    LGD-4033 Modulator
    LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity.
  • HY-B0561
    Spironolactone Antagonist
    Spironolactone is a potent antagonist of the androgen receptor.
  • HY-70002A
    N-desmethyl Enzalutamide
    N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
  • HY-B0022
    Flutamide Antagonist
    Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
  • HY-16079
    AZD3514 Inhibitor
    AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.
  • HY-18102
    GLPG0492 Modulator
    GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.
  • HY-B0626
    Testosterone undecanoate Agonist
    Testosterone undecanoate is an ester of testosterone; used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.
  • HY-12360
    Trenbolone acetate Agonist
    Trenbolone acetate (TBA; RU1697; Finaplix) is a synthetic androgen steroid with anabolic properties.
  • HY-14383
    RAD140 Inhibitor
    RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM).
  • HY-13604
    Cyproterone acetate Antagonist
    Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.