1. GPCR/G Protein
  2. Angiotensin Receptor

Angiotensin Receptor

Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-13948
    Angiotensin II human Modulator
    Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.
  • HY-17512A
    Losartan potassium Antagonist
    Losartan (potassium) is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
  • HY-15778
    AVE 0991 Agonist
    AVE 0991 is a nonpeptide and orally active Ang-(1-7) agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21±35 nM.
  • HY-12403
    Angiotensin 1-7 Inhibitor
    Angiotensin (1-7) inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM.
  • HY-18204
    Valsartan Antagonist
    Valsartan (Angiotan or Diovan), a nonpeptide angiotensin II AT1 receptor antagonist, is indicated for treatment of high blood pressure, congestive heart failure (CHF), or post-myocardial infarction (MI).
  • HY-17004
    Olmesartan Antagonist
    Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
  • HY-13955
    Telmisartan Antagonist
    Telmisartan(BIBR 277) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension.
  • HY-18204A
    LCZ696 Inhibitor
    LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
  • HY-10259A
    PD 123319 ditrifluoroacetate Antagonist
    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
  • HY-15778A
    AVE 0991 sodium salt Agonist
    AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21±35 nM.
  • HY-12405
    CGP-42112 Antagonist
    CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.
  • HY-B0195
    Tranilast Inhibitor
    Tranilast is an antiallergic agent.
  • HY-B0202
    Irbesartan Antagonist
    Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
  • HY-17005
    Olmesartan medoxomil Inhibitor
    Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
  • HY-B0780
    Fimasartan Antagonist
    Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure.
  • HY-15834A
    Eprosartan mesylate Antagonist
    Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.
  • HY-B0205
    Candesartan Antagonist
    Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
  • HY-14914
    Azilsartan Antagonist
    Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM.
  • HY-14736
    Azilsartan medoxomil Antagonist
    Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
  • HY-17512
    Losartan Antagonist
    Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.