1. Apoptosis
  2. Bcl-2 Family

Bcl-2 Family

Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, Bad, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. Human genes encoding proteins that belong to this family include: Bak1, Bax, Bal-2, Bok, Mcl-1.

Bcl-2 Family Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-15531
    ABT-199 Inhibitor 99.67%
    ABT-199 is a highly potent, orally bioavailable and Bcl-2-selective inhibitor with Ki of <0.01 nM.
  • HY-10087
    Navitoclax Inhibitor 99.34%
    Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (Ki < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-xL, Bcl-2 and Bcl-w.
  • HY-50907
    ABT-737 Inhibitor 98.38%
    ABT-737 is a BH3 mimetic inhibitor of Bcl-xLBcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively, and shows no inhibition against Mcl-1, Bcl-B or Bfl-1.
  • HY-100741
    S63845 Inhibitor 99.77%
    S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.
  • HY-12468
    A-1210477 Inhibitor 98.89%
    A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and >660 nM, respectively.
  • HY-102027
    FX1 Inhibitor >98.0%
    FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
  • HY-103036
    BET bromodomain inhibitor Inhibitor 99.51%
    BET bromodomain inhibitor is a potent BET inhibitor extracted from patent WO/2015/153871A2, compound example 11.
  • HY-P0300
    Bak BH3 Antagonist
    Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.
  • HY-15607A
    WEHI-539 hydrochloride Inhibitor
    WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
  • HY-19725
    A-1155463 Inhibitor 98.01%
    A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell.
  • HY-10969
    Obatoclax Antagonist 99.20%
    Obatoclax is an inhibitor targeting all antiapoptotic BCL-2 proteins and antagonizes all antiapoptotic Bcl-2-family proteins (average IC50 3 μM), including Mcl-1 (IC50 2.9 μM) and Bfl-1 (IC50 5 μM).
  • HY-P0081
    Bax inhibitor peptide V5 Inhibitor 99.79%
    Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
  • HY-19741
    A-1331852 Inhibitor 99.21%
    A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
  • HY-18628
    UMI-77 Inhibitor 98.04%
    UMI-77 is a novel selective Mcl-1 SMI inhibitor. UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
  • HY-12011
    HA14-1 Inhibitor >98.0%
    HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.
  • HY-15613
    Marinopyrrole A Inhibitor 98.07%
    Marinopyrrole (Maritoclax) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 uM, >8 fold selectivity than BCL-xl (IC50 > 80 uM).
  • HY-15341
    BAM7 Activator 98.47%
    BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
  • HY-N0087
    Gambogic Acid Inhibitor 99.86%
    Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
  • HY-15464A
    AT-101 acetic acid Inhibitor 98.48%
    AT101 acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
  • HY-17510
    Gossypol acetic acid Inhibitor 99.42%
    Gossypol-acetic acid, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic.