1. Apoptosis
  2. Bcl-2 Family

Bcl-2 Family

Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, Bad, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. Human genes encoding proteins that belong to this family include: Bak1, Bax, Bal-2, Bok, Mcl-1.

Bcl-2 Family Related Products (27):

Cat. No. Product Name Effect Purity
  • HY-15531
    ABT-199 Inhibitor
    ABT-199 is a highly potent, orally bioavailable and Bcl-2-selective inhibitor with Ki of <0.01 nM.
  • HY-10087
    Navitoclax Inhibitor
    Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (Ki < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-xL, Bcl-2 and Bcl-w.
  • HY-50907
    ABT-737 Inhibitor
    ABT-737 is a BH3 mimetic inhibitor of Bcl-xLBcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively, and shows no inhibition against Mcl-1, Bcl-B or Bfl-1.
  • HY-15607A
    WEHI-539 hydrochloride Inhibitor
    WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
  • HY-12468
    A-1210477 Inhibitor
    A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and >660 nM, respectively.
  • HY-19741
    A-1331852 Inhibitor
    A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
  • HY-19725
    A-1155463 Inhibitor
    A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell.
  • HY-P0081
    Bax inhibitor peptide V5 Inhibitor
    Bax inhibitor peptide V5 is a peptide inhibitor of Bax translocation to mitochondria.
  • HY-10969
    Obatoclax Antagonist
    Obatoclax (GX15-070) is Bcl-2 homology domain-3 (BH3) mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L) IC50 Value: 3 uM Target: Bcl-2 in vitro: Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1.
  • HY-N0087
    Gambogic Acid Inhibitor
    Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
  • HY-15341
    BAM7 Activator
    BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
  • HY-12011
    HA14-1 Inhibitor
    HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.
  • HY-15613
    Marinopyrrole A Inhibitor
    Marinopyrrole A is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
  • HY-12527
    Pyridoclax Inhibitor
    Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.
  • HY-18628
    UMI-77 Inhibitor
    UMI-77 is a novel selective Mcl-1 SMI inhibitor. UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
  • HY-15464A
    AT-101 acetic acid Inhibitor
    AT101 acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
  • HY-15607
    WEHI-539 Inhibitor
    WEHI-539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
  • HY-12020
    TW-37 Inhibitor
    TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
  • HY-16669
    Mcl1-IN-1 Inhibitor
    Mcl1-IN-1 is a potent Mcl-1-selective inhibitor relative to the related Bcl-2 family protein Bcl-xL; demonstrated good Mcl-1 inhibition (IC50 = 2.4 uM) with no appreciable inhibition of Bcl-xL at 100 uM.
  • HY-12826
    Mcl1-IN-2 Inhibitor
    Mcl1-IN-2 is a Mcl-1 inhibitor without reported IC50 value.