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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR Related Products (51):

Cat. No. Product Name Effect Purity
  • HY-13636
    Fulvestrant Inhibitor
    Fulvestrant is a potent and specific inhibitor of estrogen action with IC50 of 9.4 nM for Estrogen Receptor.
  • HY-13757A
    Tamoxifen Inhibitor
    Tamoxifen is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors.
  • HY-13757
    Tamoxifen Citrate Inhibitor
    Tamoxifen Citrate is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors.
  • HY-B0141
    Estradiol Agonist
    Estradiol is a human sex hormone and steroid, and the primary female sex hormone.
  • HY-12870
    AZD9496 Antagonist
    AZD9496 is a potent and selective estrogen receptor (ERα)antagonist with IC50 of 0.28 nM.
  • HY-101271
    WAY-200070 Agonist
    WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
  • HY-101405
    Gestrinone Inhibitor
    Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM.
  • HY-N2335
    Coumestrol Inhibitor
    Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.
  • HY-14590
    Kaempferol Inhibitor
    Kaempferol inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.
  • HY-12864
    GDC-0810 Inhibitor
    GDC-0810 is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.
  • HY-10426
    XCT790 Agonist
    XCT-790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα); induces cell death in chemotherapeutic resistant cancer cells.
  • HY-13738A
    Raloxifene hydrochloride Antagonist
    RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist.
  • HY-A0038
    Lasofoxifene Tartrate Modulator
    Lasofoxifene Tartrate is a non-steroidal selective estrogen receptor modulator (SERM).
  • HY-A0036
    Bazedoxifene acetate Modulator
    Bazedoxifene acetate (TSE 424; WAY-TES 424), a novel selective estrogen receptor modulator (SERM), has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues.
  • HY-B0652
    Etonogestrel Agonist
    Etonogestrel is a steroidal progestin used in hormonal contraceptives.
  • HY-B0005
    Toremifene Citrate Modulator
    Toremifene Citrate(NK 622; FC 1157a) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
  • HY-15449
    Kaempferide Inhibitor
    Kaempferide is an O-methylated flavonol, a type of chemical compound.
  • HY-N0835
    (20S)-Protopanaxatriol Modulator
    (20S)-Protopanaxatriol(g-PPT) is a metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor
    Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.
  • HY-N0322
    Cholesterol Agonist
    Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated.