1. GPCR/G Protein
  2. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-N0583
    Hydrocortisone Agonist
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
  • HY-14648
    Dexamethasone Agonist
    Dexamethasone is a glucocorticoid receptor agonist.
  • HY-13683
    Mifepristone Antagonist
    Mifepristone is a progesterone receptor (PR) antagonist (IC50=0.2 nM) in a T47D cell-based assay, also is a glucocorticoid receptor (GR) antagonist (IC50=2.6 nM) in an A549 cell-based assay.
  • HY-B0214
    Prednisone Agonist
    Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
  • HY-17463
    Prednisolone Agonist
    Prednisolone is a glucocorticoid with the general properties of the corticosteroids.
  • HY-15709
    AL 082D06 Antagonist
    AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM.
  • HY-B0154
    Fluticasone propionate Agonist
    Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
  • HY-13580
    Budesonide Agonist
    Budesonide is a glucocorticoid used in the management of asthma.
  • HY-13600
    Clobetasol propionate Agonist
    Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.
  • HY-17461
    Cortisone Agonist
    Cortisone is a 21-carbon steroid hormone. Cortisone is one of the main hormones released by the adrenal gland in response to stress.
  • HY-77839
    Cortodoxone Agonist
    Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).
  • HY-13693
    Mometasone furoate Agonist
    Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor.
  • HY-B0328
    Triamcinolone Inhibitor
    Triamcinolone is a long-acting synthetic corticosteroid.
  • HY-B0485
    Fluocinonide Agonist
    Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.
  • HY-B0260
    Methylprednisolone Agonist
    Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
  • HY-13571A
    Beclometasone dipropionate Agonist
    Beclometasone dipropionate is a potent glucocorticoid agonist; it is a prodrug of the free form, beclometasone.
  • HY-17461A
    Cortisone acetate Agonist
    Cortisone acetate (17-hydroxy-11-dehydrocorticosterone), a 21-carbon steroid hormone, is one of the main hormones released by the adrenal gland in response to stress.
  • HY-B0625
    Ciclesonide Agonist
    Ciclesonide(RPR251526) is a glucocorticoid used to treat obstructive airway diseases.
  • HY-13570A
    Betamethasone hydrochloride Agonist
    Betamethasone (hydrochloride) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
  • HY-B0243
    Meprednisone Agonist
    Meprednisone is a glucocorticoid and a methylated derivative of prednisone.