1. GPCR/G Protein
  2. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor Related Products (36):

Cat. No. Product Name Effect Purity
  • HY-N0583
    Hydrocortisone Agonist 99.66%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
  • HY-14648
    Dexamethasone Agonist 98.70%
    Dexamethasone is a glucocorticoid receptor agonist.
  • HY-13683
    Mifepristone Antagonist 98.17%
    Mifepristone is a progesterone receptor (PR) antagonist (IC50=0.2 nM) in a T47D cell-based assay, also is a glucocorticoid receptor (GR) antagonist (IC50=2.6 nM) in an A549 cell-based assay.
  • HY-B0214
    Prednisone Agonist 99.13%
    Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
  • HY-17463
    Prednisolone Agonist 99.86%
    Prednisolone is a glucocorticoid with the general properties of the corticosteroids.
  • HY-B0636
    Triamcinolone acetonide Agonist 99.96%
    Triamcinolone Acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone.
  • HY-13580
    Budesonide Agonist 98.28%
    Budesonide is a glucocorticoid used in the management of asthma.
  • HY-13600
    Clobetasol propionate Agonist
    Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.
  • HY-B0154
    Fluticasone propionate Agonist 99.77%
    Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
  • HY-N0835
    (20S)-Protopanaxatriol Modulator 99.97%
    (20S)-Protopanaxatriol(g-PPT) is a metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
  • HY-B0328
    Triamcinolone Inhibitor 99.15%
    Triamcinolone is a long-acting synthetic corticosteroid.
  • HY-15709
    AL 082D06 Antagonist
    AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM).
  • HY-B0485
    Fluocinonide Agonist
    Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.
  • HY-B0260
    Methylprednisolone Agonist 99.32%
    Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
  • HY-17461
    Cortisone Agonist 98.08%
    Cortisone is a 21-carbon steroid hormone. Cortisone is one of the main hormones released by the adrenal gland in response to stress.
  • HY-77839
    Cortodoxone Agonist 99.35%
    Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).
  • HY-B1121
    Flunisolide Activator
    Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.
  • HY-B1183
    Hydrocortisone acetate Agonist 99.07%
    Hydrocortisone acetate is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids.
  • HY-13571A
    Beclometasone dipropionate Agonist 99.90%
    Beclometasone dipropionate is a potent glucocorticoid agonist; it is a prodrug of the free form, beclometasone.
  • HY-17461A
    Cortisone acetate Agonist 99.26%
    Cortisone acetate (17-hydroxy-11-dehydrocorticosterone), a 21-carbon steroid hormone, is one of the main hormones released by the adrenal gland in response to stress.