1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Kinesin

Kinesin

Kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo. Most kinesins walk towards the plus end of a microtubule, entails transporting cargo from the centre of the cell towards the periphery. Kinesins were discovered as microtubule (MT)-based anterograde intracellular transport motors. The founding member of this superfamily, the genomes of mammals encode more than 40 kinesin proteins, organized into at least 14 families named kinesin-1 through kinesin-14.

Kinesin Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-15187
    ARRY-520 Inhibitor 99.41%
    ARRY-520 is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
  • HY-10299
    GSK-923295 Inhibitor 99.77%
    GSK-923295 is a special, allosteric inhibitor of CENP-E kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.
  • HY-15948
    Kif15-IN-1 Inhibitor 99.04%
    Kif15-IN-1 is a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in tumor cell lines.
  • HY-15857
    CW-069 Inhibitor >98.0%
    CW-069 is a novel and allosteric inhibitor of the microtubule motor protein HSET with IC50 value of 75 ± 20 μM; shows statistically significant selectivity over KSP.
  • HY-15949
    Kif15-IN-2 Inhibitor
    Kif15-IN-2 is a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in tumor cell lines.
  • HY-15000
    EMD534085 Inhibitor 98.61%
    EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
  • HY-101071A
    Monastrol Inhibitor 99.89%
    Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
  • HY-14846A
    Litronesib Racemate 99.00%
    Litronesib Racemate is the racemate of litronesib.
  • HY-50759
    Ispinesib Inhibitor 98.75%
    Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.
  • HY-15187A
    ARRY-520 R enantiomer Inhibitor
    ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
  • HY-14846
    Litronesib Inhibitor
    Litronesib is a selective, allosteric inhibitor of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing.
  • HY-12660
    MPI-0479605 Inhibitor
    MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.
  • HY-12069
    SB-743921 Inhibitor 98.25%
    SB-743921 is a second generation, highly potent and active KSP inhibitor with Ki of 0.1 nM; no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.
  • HY-100816
    Rbin-1 Inhibitor >98.0%
    Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis.
  • HY-19530
    PF-2771 Inhibitor
    PF-2771 is a potent, selective CENP-E inhibitor, PF-2771 inhibits CENP-E motor activity with an IC50 of 16.1 ± 1.2 nM.
  • HY-19944
    Dimethylenastron Inhibitor
    Dimethylenastron is an Eg5 inhibitor, which arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
  • HY-19966
    K858 Inhibitor
    K858 selectively inhibits Eg5 ATPase activity with an IC50 of 1.3 μM.
  • HY-101298
    Paprotrain Inhibitor
    Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2 and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.