1. Immunology/Inflammation
  2. NO Synthase

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-18731
    1400W Dihydrochloride Inhibitor >98.0%
    1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.
  • HY-N0455A
    L-Arginine hydrochloride Activator >98.0%
    L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
  • HY-19504
    AVE-3085 Activator
    AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.
  • HY-N0455
    L-Arginine Activator
    L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
  • HY-102015
    6-Biopterin 98.02%
    6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
  • HY-N2300
    Kuwanon A Inhibitor
    Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.
  • HY-12116
    L-NIL Inhibitor
    L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 3.3 and 92 μM for mouse inducible NO synthase and rat brain constitutive NO synthase, respectively.
  • HY-101238
    Agmatine sulfate Inhibitor >98.0%
    Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis.