1. Membrane Transporter/Ion Channel
  2. Na+/Ca2+ Exchanger

Na+/Ca2+ Exchanger

Na+/Ca2+ exchanger (sodium-calcium exchanger , NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). Na+/Ca2+ exchanger removes a single calcium ion in exchange for the import of three sodium ions. Na+/Ca2+ exchanger exists in many different cell types and animal species. Na+/Ca2+ exchanger is considered one of the most important cellular mechanisms for removing Ca2+. The Na+/Ca2+ exchanger does not bind very tightly to Ca2+ (has a low affinity), but it can transport the ions rapidly (has a high capacity), transporting up to five thousand Ca2+ ions per second. The Na+/Ca2+ exchanger also likely plays an important role in regaining the cell's normal calcium concentrations after an excitotoxic insult.

Na+/Ca2+ Exchanger Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-15515
    SEA0400 Inhibitor 99.89%
    SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
  • HY-15415
    KB-R7943 mesylate Inhibitor 99.39%
    KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.
  • HY-19062
    SM-6586 Inhibitor
    SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.