1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT Related Products (26):

Cat. No. Product Name Effect Purity
  • HY-12000
    AG-490 Inhibitor 98.86%
    AG-490 is an tyrosine kinase inhibitor, inhibits EGFR and Stat-3.
  • HY-15312
    WP1066 Inhibitor 99.60%
    WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2, but not JAK1 and JAK3.
  • HY-N0174
    Cryptotanshinone Inhibitor 98.51%
    Cryptotanshinone(Tanshinone c) is a potent STAT3 inhibitor(IC50 =4.6 uM); inhibited STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells.
  • HY-B0497
    Niclosamide Inhibitor 98.88%
    Niclosamide is an inhibitor of STAT with IC50 of 0.7 μM and inhibits DNA replication in a cell-free assay.
  • HY-13919
    Napabucasin Inhibitor >98.0%
    Napabucasin is a newly found small molecule with the ability to inhibit gene transcription of STAT3, which is able to suppress cancer stemness properties and induce cell death.
  • HY-100614
    AS1517499 Inhibitor 99.17%
    AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
  • HY-100493
    BP-1-102 Inhibitor 99.23%
    BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3.
  • HY-100494
    SH5-07 Inhibitor >98.0%
    SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9±0.6 μM in in vitro assay.
  • HY-15146
    NSC 74859 Inhibitor 98.90%
    NSC 74859 is a chemical probe inhibitor of Stat3 activity, selectively inhibits Stat3 DNA-binding activity in vitro with IC50 of 86±33 μM.
  • HY-14944
    Homoharringtonine Inhibitor
    Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree.
  • HY-16975
    SH-4-54 Inhibitor >98.0%
    SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor, strongly binds to STAT3 protein (KD = 300 nM), is selective for STAT3 over STAT1.
  • HY-13818
    Stattic Inhibitor >98.0%
    Stattic is a potent inhibitor of STAT3, used for cancer treatment.
  • HY-B0083
    Leflunomide Activator 98.89%
    Leflunomide is a disease-modifying antirheumatic drug, and activator of transcription (STAT6) pathway.
  • HY-100453
    HO-3867 Inhibitor 99.38%
    HO-3867 a selective and potent inhibit STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.
  • HY-N0156
    Oleanolic Acid Inhibitor 98.00%
    Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.
  • HY-B1436
    Nifuroxazide Inhibitor >98.0%
    Nifuroxazide is an inhibitor of STAT activation and signaling activity, is an oral nitrofuran antibiotic, used to treat colitis and diarrhea in humans and non-humans.
  • HY-N0038
    Alantolactone Activator 99.69%
    Alantolactone(Alant camphor) is a sesquiterpene lactone; has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.
  • HY-N0897
    Corylifol A Inhibitor
    Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).
  • HY-N2312
    Mogrol Inhibitor 98.06%
    Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
  • HY-N0751
    Scutellarin Inhibitor
    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.