1. NF-κB
  2. TAK1

TAK1

TAK1 (Transforming growth factor activated kinase-1), a member of the mitogen-activated protein kinase kinase kinase family, has emerged as a key regulator of signal transduction cascades leading to the activation of the transcription factors nuclear factor-kappa B (NF- B) and activator protein-1 (AP-1). Stimulation of cells with cytokines and microbial pathogens results in the activation of TAK1, which subsequently activates I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases, culminating in the activation of NF- B and AP-1, respectively. Polyubiquitination of signalling proteins through lysine (Lys)-63-linked polyubiquitin chains plays an important role in the activation of TAK1 and IKK.

TAK1 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-15434
    NG25 Inhibitor 98.05%
    NG25 is an inhibitor of TAK1 that inhibits the activation of IKKα/IKKβ, suppresses IFNβ secretion and blocks the activation of STAT1.
  • HY-103490
    Takinib Inhibitor 98.00%
    Takinib is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM.