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Thyroid Hormone Receptor

The thyroid hormone receptor (THR) is a type of nuclear receptor which belongs to a superfamily of eukaryotic transcription factors. It regulates gene expression in response to binding small, hydrophobic ligands. The receptors exhibits a modular structure, with functionally separable domains. The most highly conserved domains are the DNA-binding domain (DBD) and the ligand-binding domain (LBD). The DBD recognizes the specific DNA responses element for the receptor. The LBD participates in several activities, including hormone binding, homo- and/or heterodimerization, formation of heat-shock-protein complex, and transcriptional activation and repression. Unliganded thyroid hormone receptors are bound to DNA thyroid hormone response elements predominantly as homodimers, or as heterodimers with retinoid X-receptors, and are associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator. Hormone binding induces changes in receptor conformation that control these properties and influence gene expression.

Thyroid Hormone Receptor Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-A0070A
    3,3',5-Triiodo-L-thyronine Activator 99.23%
    3,3',5-Triiodo-L-thyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
  • HY-14823
    Sobetirome Agonist >98.0%
    Sobetirome is a thyroid hormone receptor β (TRβ)-specific agonist, Sobetirome is designed to bind selectively to TRβ-1 with EC50 of 0.16 μM.
  • HY-A0070
    3,3',5-Triiodo-L-thyronine sodium Activator 99.22%
    3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
  • HY-18341A
    L-Thyroxine sodium salt pentahydrate 99.85%
    L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
  • HY-12216
    MGL-3196 Agonist 99.43%
    MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM.
  • HY-101406
    Thyroxine sulfate >98.0%
    Thyroxine sulfate is a thyroid hormone metabolite.
  • HY-B1201
    Tiratricol 98.07%
    Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects.
  • HY-18341
    L-Thyroxine
    L-Thyroxine (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
  • HY-P0002A
    Protirelin Acetate Activator 99.58%
    Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
  • HY-P0002
    Protirelin Activator
    Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.