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Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.

For research use only. We do not sell to patients.

Tenosal Chemical Structure

Tenosal Chemical Structure

CAS No. : 95232-68-1

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Description

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.

In Vivo

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties. Extraction recovery measured is on average 95.75% for Tenosal, 98.71% for salicylic acid (SA) and 91.11% for TA. In the whole analysis of Tenosal extracted from plasma, the inter-assay coefficient of variation (C.V.) ranges from 1.00 to 5.86% and the intra assay C.V. is 5.01%. The administration of Tenosal allows a higher bioavailability of SA to be achieved than after dosing with ASA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.25

Formula

C12H8O4S

CAS No.
SMILES

O=C(C1=CC=CS1)OC2=CC=CC=C2C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
Animal Administration
[1]

Both sexes of albino Sprague-Dawley rats (175 to 200 g body weight) are used for the experiment. Before the trial the animals are caged for seven days at 21 to 22°C and 55 to 75% relative humidity with a cycle of 12 h light-12 h dark. The animals are orally treated with Tenosal (300 mg/kg) or ASA (220 mg/kg) by a gastric gavage, both substances being suspended in 2% arabic gum. Six animals per group are killed at times 0 (baseline), 0.5, 1, 2, 4, 8, 16 and 24 h. Heparinized blood is sampled and centrifuged to obtain plasma. Liver, kidneys, lungs, myocardium, gastric wall and intestinal wall are also sampled from the animals killed 0, 1, 2, 4, 8 and 16 h after dosing. All the samples are stored in a freezer at -20°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Tenosal Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Tenosal
Cat. No.:
HY-12384
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