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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Thalidomide

HY-14658

Thalidomide
Thalidomide Chemical Structure

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.

Price and Availability of Thalidomide
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Thalidomide Data Sheet
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    DataSheet

Thalidomide

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Biological Activity of Thalidomide

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.
IC50 value:
Target:
Thalidomide was commonly used therapeutically in the late 1950's; however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogenic and immunomodulatory activities. This compound has been shown to: selectively inhibit tumor necrosis factor-alpha (TNF alpha) biosynthesis and basic fibroblast growth factor (bFGF)-induced angiogenesis, induce apoptosis in human monocytes via a cytochrome c-dependent pathway, and to inhibit HIV-1 replication in a monocytoid (U1) line. These new found uses make Thalidomide an extremely valuable research tool.

Clinical Information of Thalidomide

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[1]. Prommer EE. Palliative oncology: thalidomide. Am J Hosp Palliat Care. 2010 May;27(3):198-204. doi: 10.1177/1049909109348981.

[2]. Zhang S, Li M, Gu Y et al. Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J Exp Clin Cancer Res. 2008 Nov 4;27:60. doi: 10.1186/1756-9966-27-60.

[3]. Gockel HR, Lügering A, Heidemann J et al. Thalidomide induces apoptosis in human monocytes by using a cytochrome c-dependent pathway. J Immunol. 2004 Apr 15;172(8):5103-9.

[4]. Boireau A, Bordier F, Dubédat P, et al. Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci Lett. 1997 Oct 3;234(2-3):123-6.

[5]. Makonkawkeyoon S, Limson-Pobre RN, Moreira AL et al. Thalidomide inhibits the replication of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5974-8.

Products are for research use only. Not for human use. We do not sell to patients.

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