1. Tyloxapol

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals.

For research use only. We do not sell to patients.

Tyloxapol Chemical Structure

Tyloxapol Chemical Structure

CAS No. : 25301-02-4

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Based on 1 publication(s) in Google Scholar

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Description

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals[1][2].

In Vitro

Tyloxapol (100 μg/mL) triggers the detachment of HEK293 cells[2].
Tyloxapol induces nuclear fragmentation and the appearance of apoptotic nuclei[2].
Tyloxapol increases the risk of pulmonary haemorrhage, causes cytotoxicity in epithelial and red blood cells, and induces lysis of human Jurkat T-lymphoblasts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tyloxapol (Triton WR1339, 50 mg/kg) causes significant (P?< 0.05) decreases in the activities of the AChE and MAO enzymes in rat plasma and brain[1].
? Tyloxapol leads to significant (P?< 0.05) reduction in the plasma urea, creatinine, and bilirubin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Twenty-one adult male Wistar rats, aged 11–12 weeks weighing 180-200 g[1].
Dosage: 50 mg/kg.
Administration: Injected intraperitoneally, BW, every other day.
Result: Caused a significant (P < 0.05) elevation in the levels of TBARS combined with an inhibition of the antioxidant enzymes (GPx, GST, CAT, SOD) in rat plasma, liver, and brain.
Induced DNA fragmentation and inhibited the activities of acetylcholinesterase and mono aminoxidase in the brain.
Molecular Weight

261.38 (monomer)

Formula

(C15H21O(C2H4O)m)n

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[H]OCCOC1=C(CC)C=C(C(CC(C)(C)C)(C)C)C=C1C.[6].[=].[<].[5].[8].[n].[m].[_].[=].[m].[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 120 mg/mL (Need ultrasonic)

Ethanol : 100 mg/mL (Need ultrasonic)

DMSO : ≥ 38 mg/mL

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Tyloxapol
Cat. No.:
HY-B1068
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