2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. UK-240455

UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist.

For research use only. We do not sell to patients.

UK-240455 Chemical Structure

UK-240455 Chemical Structure

CAS No. : 178908-09-3

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Description

UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist.

IC50 & Target

NMDA Receptor

 

In Vivo

UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. Following i.v. administration of UK-240455 to male rats, UK-240455 has a clearance of 12 mL/min/kg and a volume of distribution of 0.4 L/kg. The plasma concentration of UK-240455 decreases with an apparent half-life of 0.4 h. Analysis of urine (0 to 24 h) for unchanged UK-240455 indicates that 57% of the dose administered is excreted unchanged in the urine. The urinary clearance of UK-240455 in the rat is therefore 7 mL/min/kg. Following oral administration of UK-240455 to male rats, the apparent elimination half-life of UK-240455 from plasma following oral administration is 1.6 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

368.19

Formula

C11H11Cl2N3O5S
CAS No.
SMILES

CS(=O)(N(C1=C(Cl)C(Cl)=CC(NC2=O)=C1NC2=O)CCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

UK-240455 is administered both i.v. and orally at a dose of 2 mg/kg to male rats. Before and during the i.v. and oral studies, animals have free access to food and water. For i.v. studies, UK-240455 is administered to rats (250 to 300 g) via the tail vein. At the following time points (n=3/time point) blood samples are taken under terminal anaesthesia: predose, 0.1, 0.25, 0.5, 1.0, 1.5, 2.0, 4.0 and 7.0 h postdose. Blood samples are collected into heparinized tubes and centrifuged to separate plasma. The plasma is removed and stored frozen. Three further rats are dosed with UK-240455 as above and placed in metabolism cages to collect urine. After 24 h, these animals are killed and the urine collected and stored frozen[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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UK-240455 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK-240455178908-09-3UK240455UK 240455iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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