1. Neuronal Signaling
  2. Serotonin Transporter
  3. Venlafaxine

Venlafaxine  (Synonyms: Wy 45030)

Cat. No.: HY-B0196 Purity: 99.94%
COA Handling Instructions

Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.

For research use only. We do not sell to patients.

Venlafaxine Chemical Structure

Venlafaxine Chemical Structure

CAS No. : 93413-69-5

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 46 In-stock
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10 mg USD 66 In-stock
50 mg USD 131 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Venlafaxine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Venlafaxine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].

In Vitro

Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM[1].
Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED50 values of 2 and 54 mg/kg, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 180-230 grams[1]
Dosage: 10, 30, 100 mg/kg
Administration: IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)
Result: Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED50 values of 12 and 94 mg/kg, respectively.
Clinical Trial
Molecular Weight

277.40

Formula

C17H27NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (901.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6049 mL 18.0245 mL 36.0490 mL
5 mM 0.7210 mL 3.6049 mL 7.2098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6049 mL 18.0245 mL 36.0490 mL 90.1226 mL
5 mM 0.7210 mL 3.6049 mL 7.2098 mL 18.0245 mL
10 mM 0.3605 mL 1.8025 mL 3.6049 mL 9.0123 mL
15 mM 0.2403 mL 1.2016 mL 2.4033 mL 6.0082 mL
20 mM 0.1802 mL 0.9012 mL 1.8025 mL 4.5061 mL
25 mM 0.1442 mL 0.7210 mL 1.4420 mL 3.6049 mL
30 mM 0.1202 mL 0.6008 mL 1.2016 mL 3.0041 mL
40 mM 0.0901 mL 0.4506 mL 0.9012 mL 2.2531 mL
50 mM 0.0721 mL 0.3605 mL 0.7210 mL 1.8025 mL
60 mM 0.0601 mL 0.3004 mL 0.6008 mL 1.5020 mL
80 mM 0.0451 mL 0.2253 mL 0.4506 mL 1.1265 mL
100 mM 0.0360 mL 0.1802 mL 0.3605 mL 0.9012 mL
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Venlafaxine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Venlafaxine
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