2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Veralipride

Veralipride  (Synonyms: (±)-Veralipride; LIR166)

Cat. No.: HY-101797 Purity: 99.57%
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Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.

For research use only. We do not sell to patients.

Veralipride Chemical Structure

Veralipride Chemical Structure

CAS No. : 66644-81-3

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Veralipride Related Antibodies

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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Description

Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.

In Vitro

Veralipride administration (100 mg/day for 30 days) induces a significant reduction in vasomotor symptoms and is more effective than placebo. Treatment is followed by the expected increase in plasma prolactin levels and by a significant decrease in mean plasma LH. A significant reduction is observed in objectively recorded hot flushes after Veralipride treatment[1]. Veralipride is well absorbed when administered orally, achieving maximal concentrations at 2.5 hours. It is poorly metabolized and is eliminated in the urine and feces. After oral administration, the half-life is 4 hours, and 44% is excreted without any changes in urine in the first 120 hours[2]. A total of 57 adverse events are registered during the 386-month treatment. For the 20×10 dosing schedule, the highest incidence is observed for anxiety (2.2%), drowsiness, and weakness (1.5%); for the 5 × 2 dosing schedule, the highest incidence is observed for drowsiness (5.3%) and headache (2.6%)[3]. Veralipride is known to cause extrapiramidal signs such as bucco-facial or limb dyskinesia. Veralipride may cause reversible parkinsonism[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Veralipride Related Antibodies
Molecular Weight

383.46

Formula

C17H25N3O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1N(CC=C)CCC1)C2=CC(S(=O)(N)=O)=CC(OC)=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (260.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6078 mL 13.0392 mL 26.0783 mL
5 mM 0.5216 mL 2.6078 mL 5.2157 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6078 mL 13.0392 mL 26.0783 mL 65.1958 mL
5 mM 0.5216 mL 2.6078 mL 5.2157 mL 13.0392 mL
10 mM 0.2608 mL 1.3039 mL 2.6078 mL 6.5196 mL
15 mM 0.1739 mL 0.8693 mL 1.7386 mL 4.3464 mL
20 mM 0.1304 mL 0.6520 mL 1.3039 mL 3.2598 mL
25 mM 0.1043 mL 0.5216 mL 1.0431 mL 2.6078 mL
30 mM 0.0869 mL 0.4346 mL 0.8693 mL 2.1732 mL
40 mM 0.0652 mL 0.3260 mL 0.6520 mL 1.6299 mL
50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.3039 mL
60 mM 0.0435 mL 0.2173 mL 0.4346 mL 1.0866 mL
80 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8149 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6520 mL
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Veralipride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veralipride66644-81-3(±)-Veralipride LIR166LIR166LIR 166LIR-166Dopamine ReceptorInhibitorinhibitorinhibit

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