Vinconate (Synonyms: Chanodesethylapovincamine)

Cat. No.: HY-U00316: FAQs
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Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

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Vinconate Chemical Structure

CAS No. : 70704-03-9

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Description	Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.
IC₅₀ & Target	muscariic acetylcholine receptor^[1]
In Vivo	Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate^[1]. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [³H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [³H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [³H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [³H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	296.36
Formula	C₁₈H₂₀N₂O₂
CAS No.	70704-03-9
SMILES	O=C(C1=CCC2N(CC)CCC3=C2N1C4=C3C=CC=C4)OC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (278 KB) Handling Instructions (2659 KB)
References	[1]. Iino T, et al. Effect of vinconate, an indolonaphthyridine derivative, on dopamine and serotonin concentrations in dialysate from the striatum of freely moving rats: brain microdialysis studies. J Pharmacol Exp Ther. 1996 Aug;278(2):614-9. [Content Brief] [2]. Araki T, et al. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):343-9. [Content Brief]

Animal Administration
^[2]

344 male rats, 6 months (adult) and 24 months (aged) of age, are allowed food and water ad lib throughout the experiments. Rats are divided into four groups; (1) 6-month-old; (2) vehicle (distilled water) is administered intraperitoneally (i.p.) once a day for 4 weeks before decapitation; (3) Vinconate at a dose of 10 mg/kg is administered i.p. once a day for 4 weeks before decapitation; (4) Vinconate at a dose of 30 mg/kg is administered i.p. once a day for 4 weeks before decapitation. Rats in groups (2) to (4) are 24 months old. Each group contains 6 to 7 rats. In addition, there are no significant differences among the three aged animal groups in body weight after drug or vehicle treatment^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Iino T, et al. Effect of vinconate, an indolonaphthyridine derivative, on dopamine and serotonin concentrations in dialysate from the striatum of freely moving rats: brain microdialysis studies. J Pharmacol Exp Ther. 1996 Aug;278(2):614-9. [Content Brief]

[2]. Araki T, et al. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):343-9. [Content Brief]

Vinconate Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vinconate70704-03-9ChanodesethylapovincaminemAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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Vinconate (Synonyms: Chanodesethylapovinc​amine)

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