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Signaling Pathway

WEHI-345

HY-18937

WEHI-345

WEHI-345 Chemical Structure

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.

Size Price Stock Quantity
5 mg $350 Backordered
10 mg $500 Backordered
50 mg $1500 Backordered
100 mg $2100 Backordered
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
5 mg €343 Backordered
10 mg €490 Backordered
50 mg €1470 Backordered
100 mg €2058 Backordered
200 mg Get quote
500 mg Get quote

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Product name: WEHI-345
Cat. No.: HY-18937

WEHI-345 Data Sheet

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    DataSheet

Related Compound Libraries

Biological Activity of WEHI-345

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
IC50 value: 0.13 μM
Target: RIPK2
in vitro: WEHI-345 is a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. WEHI-345 is an ATP analogue and was therefore predicted to bind in the ATP-binding pocket of RIPK2. WEHI-345 proved to be highly specific for RIPK2(Kd=46 nM) and displayed negligible activity (>10 μM) against RIPK1, RIPK4 and RIPK5.
in vivo: WEHI-345 inhibits NOD signalling and has a beneficial effect on an EAE model. WEHI-345 blocks MDP-induced cytokine production. WEHI-345 ameliorates experimental autoimmune encephalomyelitis in mice. WEHI-345 also potently inhibited MDP-induced cytokine and chemokine secretion in the mouse macrophage Raw 264.7 cell line.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 401.46 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H23N7O
CAS No 1354825-58-3
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.4909 mL 12.4545 mL 24.9091 mL
5 mM 0.4982 mL 2.4909 mL 4.9818 mL
10 mM 0.2491 mL 1.2455 mL 2.4909 mL

References on WEHI-345

Inhibitor Kit