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    Autophagy
  2. Estrogen Receptor/ERR
    Autophagy

XCT790 

Cat. No.: HY-10426 Purity: 98.01%
Data Sheet SDS Handling Instructions

XCT-790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα); induces cell death in chemotherapeutic resistant cancer cells.

For research use only. We do not sell to patients.
XCT790 Chemical Structure

XCT790 Chemical Structure

CAS No. : 725247-18-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $130 In-stock
10 mg $118 In-stock
50 mg $458 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

    XCT790 purchased from MCE. Usage Cited in: Oncogene. 2016 Sep 22;35(38):5033-42.

    Inhibition of the ERRα-dependent mitochondrial activity by XCT-790 is found to drastically inhibit decreased cell density and increase cell death induced by PLA2R1.
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    • References

    Description

    XCT-790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα); induces cell death in chemotherapeutic resistant cancer cells. IC50 value: Target: ERRα ERRalpha inverse agonist XCT-790 induced cell death in HepG2 hepatocarcinoma and its multi-drug resistance (MDR) sub-line R-HepG2. Using a dye Mitotracker Green which stains mitochondrion independent of mitochondrial membrane potential (DeltaPsi(m)), XCT-790 dose-dependently decreased mitochondrial mass. Intriguingly, XCT-790 increased DeltaPsi(m) upon short term treatment but decreased DeltaPsi(m) upon longer term treatment. XCT-790 synergized with paclitaxel to induce cell death in multi-drug resistance sub-line R-HepG2 [1]. XCT790 is a potent and specific inverse agonist of ERRα. XCT790 shows no significant antagonist activity on related nuclear receptors, such as ERR or ERα at concentrations below 10 μM. This also inhibits the constitutive activity of ER (Estrogen Receptor) [2].

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 1.6767 mL 8.3834 mL 16.7667 mL
    5 mM 0.3353 mL 1.6767 mL 3.3533 mL
    10 mM 0.1677 mL 0.8383 mL 1.6767 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    596.42

    Formula

    C₂₃H₁₃F₉N₄O₃S

    CAS No.

    725247-18-7

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 21 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    XCT790
    Cat. No.:
    HY-10426
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