1. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  2. Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species
  3. Zofenopril calcium

Zofenopril calcium  (Synonyms: SQ26991)

Cat. No.: HY-B0655 Purity: 99.56%
COA Handling Instructions

Zofenopril Calcium (SQ26991) is an orally active angiotensin-converting enzyme (ACE) inhibitor with antioxidant activity and cardioprotective effects. Zofenopril Calcium reduces ROS production and GSH consumption and helps inhibit foam cell formation, thus slowing the progression of atherosclerosis. Zofenopril Calcium prevents cardiac damage caused by chronic Doxorubicin (HY-15142A).

For research use only. We do not sell to patients.

Zofenopril calcium Chemical Structure

Zofenopril calcium Chemical Structure

CAS No. : 81938-43-4

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Zofenopril Calcium (SQ26991) is an orally active angiotensin-converting enzyme (ACE) inhibitor with antioxidant activity and cardioprotective effects. Zofenopril Calcium reduces ROS production and GSH consumption and helps inhibit foam cell formation, thus slowing the progression of atherosclerosis. Zofenopril Calcium prevents cardiac damage caused by chronic Doxorubicin (HY-15142A).

In Vitro

Zofenopril calcium (30-60 μM; 30 min) decreases oxLDL-induced E-selectin, ICAM-1, and VCAM-1 expressiom in human umbilical vein endothelial (HUVEC) monolayers[1].
Zofenopril calcium (30-60 μM; 30 min) inhibits oxLDL-induced ROS and superoxide formation in HUVECs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zofenopril calcium (15 mg/kg/day; po via diet for 9 weeks) results a significant decrease in body weight, and prevents the cardiotoxic effects of doxorubicin in rats[2].
Zofenopril calcium shows no significant antitumor effect in rat A2780 xenograft model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

448.58

Formula

C22H22Ca0.5NO4S2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C[C@@H](SC1=CC=CC=C1)C2)[C@@H]2C([O-])=O)[C@H](C)CSC(C3=CC=CC=C3)=O.[0.5Ca2+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (4.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2293 mL 11.1463 mL 22.2926 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2293 mL 11.1463 mL 22.2926 mL 55.7314 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Zofenopril calcium
Cat. No.:
HY-B0655
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