1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. (R)-Zanubrutinib

(R)-Zanubrutinib  (Synonyms: (R)-BGB-3111)

Cat. No.: HY-101474B Purity: 97.08%
COA Handling Instructions

(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.

For research use only. We do not sell to patients.

(R)-Zanubrutinib Chemical Structure

(R)-Zanubrutinib Chemical Structure

CAS No. : 1691249-44-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 209 In-stock
Solution
10 mM * 1 mL in DMSO USD 209 In-stock
Solid
5 mg USD 190 In-stock
10 mg USD 350 In-stock
25 mg USD 750 In-stock
50 mg USD 1250 In-stock
100 mg USD 2000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Zanubrutinib:

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  • Biological Activity

  • Purity & Documentation

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Description

(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.

Molecular Weight

471.55

Formula

C27H29N5O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(C1=C2N(N=C1C3=CC=C(OC4=CC=CC=C4)C=C3)[C@@H](C5CCN(C(C=C)=O)CC5)CCN2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 64.25 mg/mL (136.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1207 mL 10.6033 mL 21.2067 mL
5 mM 0.4241 mL 2.1207 mL 4.2413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.08%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1207 mL 10.6033 mL 21.2067 mL 53.0166 mL
5 mM 0.4241 mL 2.1207 mL 4.2413 mL 10.6033 mL
10 mM 0.2121 mL 1.0603 mL 2.1207 mL 5.3017 mL
15 mM 0.1414 mL 0.7069 mL 1.4138 mL 3.5344 mL
20 mM 0.1060 mL 0.5302 mL 1.0603 mL 2.6508 mL
25 mM 0.0848 mL 0.4241 mL 0.8483 mL 2.1207 mL
30 mM 0.0707 mL 0.3534 mL 0.7069 mL 1.7672 mL
40 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3254 mL
50 mM 0.0424 mL 0.2121 mL 0.4241 mL 1.0603 mL
60 mM 0.0353 mL 0.1767 mL 0.3534 mL 0.8836 mL
80 mM 0.0265 mL 0.1325 mL 0.2651 mL 0.6627 mL
100 mM 0.0212 mL 0.1060 mL 0.2121 mL 0.5302 mL
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(R)-Zanubrutinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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