2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (S)-MCPG

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.

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(S)-MCPG Chemical Structure

(S)-MCPG Chemical Structure

CAS No. : 150145-89-4

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-MCPG:

(S)-MCPG Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (S)-MCPG

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371)[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2].

IC50 & Target[1]

mGluR

 

In Vitro

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-MCPG Related Antibodies
In Vivo
Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze[2]
Dosage: 20 μg
Administration: Intraventricular injection; 20 μg; 4 days
Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
Molecular Weight

209.20

Formula

C10H11NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (478.01 mM; ultrasonic and adjust pH to 13 with 1M NaOH)

1M NaOH : 22 mg/mL (105.16 mM; ultrasonic and adjust pH to 11 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7801 mL 23.9006 mL 47.8011 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH / H2O 1 mM 4.7801 mL 23.9006 mL 47.8011 mL 119.5029 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL 23.9006 mL
10 mM 0.4780 mL 2.3901 mL 4.7801 mL 11.9503 mL
15 mM 0.3187 mL 1.5934 mL 3.1867 mL 7.9669 mL
20 mM 0.2390 mL 1.1950 mL 2.3901 mL 5.9751 mL
25 mM 0.1912 mL 0.9560 mL 1.9120 mL 4.7801 mL
30 mM 0.1593 mL 0.7967 mL 1.5934 mL 3.9834 mL
40 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9876 mL
50 mM 0.0956 mL 0.4780 mL 0.9560 mL 2.3901 mL
60 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
80 mM 0.0598 mL 0.2988 mL 0.5975 mL 1.4938 mL
100 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1950 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S)-MCPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-MCPG150145-89-4(+)-MCPGmGluRMetabotropic glutamate receptorsabotropic receptorNMDA receptorsbehaviorlearning. memoryspatialfear metabotropicisomerInhibitorinhibitorinhibit

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