2. Pirmenol

Pirmenol  (Synonyms: (±)-Pirmenol; CI-845 free base)

Cat. No.: HY-100795
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Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Pirmenol hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Pirmenol Chemical Structure

Pirmenol Chemical Structure

CAS No. : 68252-19-7

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Pirmenol Related Antibodies

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Description

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4].

IC50 & Target

IC50: 0.1 μM (IK.ACh)[1]
In Vitro

Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells[1].
Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes[3].
Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pirmenol Related Antibodies
In Vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4].
Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2].
Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Conscious, coronary artery ligated dogs[4]
Dosage: Oral administration (p.o.)
Administration: 2.5 and 5 mg/kg
Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.
Molecular Weight

338.49

Formula

C22H30N2O
CAS No.
SMILES

OC(C1=CC=CC=C1)(CCCN2[C@@H](C)CCC[C@H]2C)C3=CC=CC=N3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pirmenol68252-19-7(±)-PirmenolCI-845CI845CI 845Inhibitorinhibitorinhibit

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