2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. α-MSH

α-MSH  (Synonyms: α-Melanocyte-Stimulating Hormone)

Cat. No.: HY-P0252 Purity: 99.57%
COA Handling Instructions

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α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-MSH Chemical Structure

α-MSH Chemical Structure

CAS No. : 581-05-5

Size Price Stock Quantity
1 mg USD 66 In-stock
5 mg USD 198 In-stock
10 mg USD 343 In-stock
25 mg USD 739 In-stock
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100 mg   Get quote  

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Based on 10 publication(s) in Google Scholar

Other Forms of α-MSH:

α-MSH Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].

IC50 & Target

MC4R

 

In Vitro

α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-MSH Related Antibodies
In Vivo

α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IL-10–deficient mice[3]
Dosage: 50 µg/0.2 ml saline
Administration: I.p.
Result: Given systemically effectively modulated inflammatory reactions.
Molecular Weight

1664.88

Formula

C77H109N21O19S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Sequence Shortening

Ac-SYSMEHFRWGKPV-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (60.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 12.5 mg/mL (7.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6006 mL 3.0032 mL 6.0064 mL
5 mM 0.1201 mL 0.6006 mL 1.2013 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.57%

COA (251 KB) RP-HPLC (223 KB) Elemental Analysis Report (110 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.6006 mL 3.0032 mL 6.0064 mL 15.0161 mL
5 mM 0.1201 mL 0.6006 mL 1.2013 mL 3.0032 mL
DMSO 10 mM 0.0601 mL 0.3003 mL 0.6006 mL 1.5016 mL
15 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0011 mL
20 mM 0.0300 mL 0.1502 mL 0.3003 mL 0.7508 mL
25 mM 0.0240 mL 0.1201 mL 0.2403 mL 0.6006 mL
30 mM 0.0200 mL 0.1001 mL 0.2002 mL 0.5005 mL
40 mM 0.0150 mL 0.0751 mL 0.1502 mL 0.3754 mL
50 mM 0.0120 mL 0.0601 mL 0.1201 mL 0.3003 mL
60 mM 0.0100 mL 0.0501 mL 0.1001 mL 0.2503 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-MSH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-MSH581-05-5α-Melanocyte-Stimulating HormoneMelanocortin ReceptorMC Receptoralpha-melanocyte-stimulatinghormoneendogenousanti-inflammatoryneuroimmunomodulatorypeptideinflammationInhibitorinhibitorinhibit

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