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AR-C155858

HY-13248

(AR C155858)

AR-C155858

AR-C155858 Chemical Structure

AR-C155858 is a novel inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and <10 nM respectively); exhibits no activity at MCT4.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $351 In-stock
5 mg $319 In-stock
10 mg $528 In-stock
50 mg $1320 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €344 In-stock
5 mg €313 In-stock
10 mg €517 In-stock
50 mg €1294 In-stock
100 mg Get quote
200 mg Get quote

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Product name: AR-C155858
Cat. No.: HY-13248

AR-C155858 Data Sheet

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    Purity: 95.17% ee.:99.34%

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Biological Activity of AR-C155858

AR-C155858 is a novel inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and <10 nM respectively); exhibits no activity at MCT4.
IC50 value: 2.3/<10 nM (Ki, MCT1/2) [1] [2]
Target: MCT1/2
in vitro: Co-expression of exogenous embigin was without effect on either the expression of MCT1 or its inhibition by AR-C155858. In contrast, expression of active MCT2 at the plasma membrane of oocytes was significantly enhanced by co-expression of exogenous embigin. This additional transport activity was insensitive to inhibition by AR-C155858 unlike that by MCT2 expressed with endogenous basigin that was potently inhibited by AR-C155858 [1]. Derived values were 2.3+/-1.4 nM, 1.29+/-0.09 nmol per ml of packed cells and 12.2+/-1.1 s-1 respectively. When expressed in Xenopus laevis oocytes, MCT1 and MCT2 were potently inhibited by AR-C155858, whereas MCT4 was not. Inhibition of MCT1 was shown to be time-dependent, and the compound was also active when microinjected, suggesting that AR-C155858 probably enters the cell before binding to an intracellular site on MCT1 [2].
in vivo:

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 461.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H27N5O5S
CAS No 496791-37-8
Solvent & Solubility

in DMSO > 10 mM

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1667 mL 10.8335 mL 21.6671 mL
5 mM 0.4333 mL 2.1667 mL 4.3334 mL
10 mM 0.2167 mL 1.0834 mL 2.1667 mL

References on AR-C155858

Inhibitor Kit

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