2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Ceftazidime

Ceftazidime  (Synonyms: GR20263)

Cat. No.: HY-B0593 Purity: 99.72%
COA Handling Instructions

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Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.

For research use only. We do not sell to patients.

Ceftazidime Chemical Structure

Ceftazidime Chemical Structure

CAS No. : 72558-82-8

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Solid + Solvent
10 mM * 1 mL in DMSO
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5 g USD 90 In-stock
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Based on 20 publication(s) in Google Scholar

Other Forms of Ceftazidime:

Ceftazidime Related Antibodies

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  • Biological Activity

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Description

Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases[1].

IC50 & Target

β-lactam

 

In Vitro

Ceftazidime (0-8 μg/mL approximately, 24 h) displays antibacterial and anti-biofilm activities against P. aeruginosa strains[2].
Ceftazidime (0-40 μg/mL approximately, 18-20 h) has inhibitory activities against S. maltophilia isolates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ceftazidime Related Antibodies

Cell Viability Assay[2]

Cell Line: P. aeruginosa strains (PAO1, PA1, PA2)
Concentration: 0-8 µg/mL approximately
Incubation Time: 24 h
Result: Displayed antibacterial and anti-biofilm activities with MIC values of 2-4 µg/mL.
In Vivo

Ceftazidime (2 h infusion of injection, 2 000 mg, every 8 h for 24 h) moderately reduces bacterial density in a murine thigh infection model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine thigh infection model[4]
Dosage: 2000 mg
Administration: 2 h infusion of injection, every 8 h for 24 h.
Result: Reduced bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain.
Clinical Trial
Molecular Weight

546.58

Formula

C22H22N6O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC(C)(C(O)=O)C)=O)[C@@]3([H])SCC(C[N+]4=CC=CC=C4)=C(C([O-])=O)N13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (182.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8296 mL 9.1478 mL 18.2956 mL
5 mM 0.3659 mL 1.8296 mL 3.6591 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (182.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

COA (256 KB) HNMR (301 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8296 mL 9.1478 mL 18.2956 mL 45.7390 mL
5 mM 0.3659 mL 1.8296 mL 3.6591 mL 9.1478 mL
10 mM 0.1830 mL 0.9148 mL 1.8296 mL 4.5739 mL
15 mM 0.1220 mL 0.6099 mL 1.2197 mL 3.0493 mL
20 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2869 mL
25 mM 0.0732 mL 0.3659 mL 0.7318 mL 1.8296 mL
30 mM 0.0610 mL 0.3049 mL 0.6099 mL 1.5246 mL
40 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL
50 mM 0.0366 mL 0.1830 mL 0.3659 mL 0.9148 mL
60 mM 0.0305 mL 0.1525 mL 0.3049 mL 0.7623 mL
80 mM 0.0229 mL 0.1143 mL 0.2287 mL 0.5717 mL
100 mM 0.0183 mL 0.0915 mL 0.1830 mL 0.4574 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ceftazidime Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceftazidime72558-82-8GR20263GR 20263GR-20263Beta-lactamaseBacterialAntibioticβ-lactamaseBiofilmGramthigh infectionlactamaseinfectionInhibitorinhibitorinhibit

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