1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Dexpramipexole

Dexpramipexole  (Synonyms: (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704)

Cat. No.: HY-17355B
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Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist.

For research use only. We do not sell to patients.

Dexpramipexole Chemical Structure

Dexpramipexole Chemical Structure

CAS No. : 104632-28-2

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Top Publications Citing Use of Products

    Dexpramipexole purchased from MedChemExpress. Usage Cited in: Neuroreport. 2023 Jan 23.  [Abstract]

    Dexpramipexole (DPX; 3 mg/kg; i.p.; once daily for 6 consecutive days) attenuates the LPS-induced increase in the number of TUNEL-positive cells in the hippocampus in SAE mice.

    Dexpramipexole purchased from MedChemExpress. Usage Cited in: Neuroreport. 2023 Jan 23.  [Abstract]

    Dexpramipexole (DPX; 3 mg/kg; i.p.; once daily for 6 consecutive days) attenuates LPS-induced activation of microglia and astrocytes in the hippocampus in SAE mice. (a) Representative images of Iba-1 staining and quantification of Iba-1 (green) fluorescence intensity in the hippocampal CA1 and DG regions. (b) Representative images of GFAP staining and quantification of GFAP (red) fluorescence intensity in the hippocampal CA1 and DG regions. DAPI staining is shown in blue.
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    Description

    Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value: Target: Dopamine Receptor Dexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

    Clinical Trial
    Molecular Weight

    211.33

    Formula

    C10H17N3S

    CAS No.
    SMILES

    NC1=NC(CC[C@@H](NCCC)C2)=C2S1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Dexpramipexole Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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