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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

JNK-IN-7

HY-15617

(JNK inhibitor)

JNK-IN-7

JNK-IN-7 Chemical Structure

JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $315 In-stock
5 mg $286 In-stock
10 mg $369 In-stock
50 mg $996 In-stock
100 mg $1588 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €309 In-stock
5 mg €280 In-stock
10 mg €362 In-stock
50 mg €976 In-stock
100 mg €1556 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: JNK-IN-7
Cat. No.: HY-15617

JNK-IN-7 Data Sheet

  • View current batch:

    Purity: 97.27%

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    DataSheet

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    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of JNK-IN-7

JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.
IC50 Value: 1.54 nM(JNK1); 1.99 nM (JNK2); 0.75 nM (JNK3)
Target: JNK1/2/3
Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM [1].
 

Chemical Information

M.Wt 493.56 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C28H27N7O2
CAS No 1408064-71-0
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.0261 mL 10.1305 mL 20.2610 mL
5 mM 0.4052 mL 2.0261 mL 4.0522 mL
10 mM 0.2026 mL 1.0130 mL 2.0261 mL

References on JNK-IN-7

[1]. Zhang, Tinghu, et al. Discovery of Potent and Selective Covalent Inhibitors of JNK. Chemistry & Biology (Oxford, United Kingdom) (2012), 19(1), 140-154.
Abstract
The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellular response. Here, we report the discovery of irreversible inhibitors of JNK1/2/3. We describe two JNK3 cocrystal structures at 2.60 and 2.97 ? resoln. that show the compds. form covalent bonds with a conserved cysteine residue. JNK-IN-8 is a selective JNK inhibitor that inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochem., cellular, and pathway-based profiling establish the selectivity of JNK-IN-8 for JNK and suggests that the compd. will be broadly useful as a pharmacol. probe of JNK-dependent signal transduction. Potential lead compds. have also been identified for kinases, including IRAK1, PIK3C3, PIP4K2C, and PIP5K3.

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