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Products are for research use only. Not for human use. We do not sell to patients.
(KU 0063794; KU0063794)
KU-0063794 Chemical Structure
|Product name: KU-0063794|
|Cat. No.: HY-50710|
KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively); no effect on PI3Ks.
IC50 value: ~10 nM 
KU-0063794 displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. KU-0063794 suppresses cell growth and induces G1 cell cycle arrest in vitro.
|M.Wt||465.54||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO ≥10mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.1480 mL||10.7402 mL||21.4804 mL|
|5 mM||0.4296 mL||2.1480 mL||4.2961 mL|
|10 mM||0.2148 mL||1.0740 mL||2.1480 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|KU-0063794||Queen Mary University of London||Metastatic renal cancer||28-FEB-13||31-DEC-15||Phase 2||15-NOV-13|
|AstraZeneca plc||Advanced solid tumor||31-DEC-09||28-FEB-14||Phase 1||06-NOV-13|
|AstraZeneca plc||Metastatic breast cancer||31-MAY-12||30-NOV-13||Phase 1||01-NOV-13|
. Collak FK, Yagiz K, Luthringer DJ, Erkaya B, Cinar B.Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.J Biol Chem. 2012 Jul 6;287(28):23698-709. Epub 2012 May 22.
. Wahdan-Alaswad RS, Bane KL, Song K, Shola DT, Garcia JA, Danielpour D.Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.Mol Cancer Res. 2012 Jun;10(6):821-33. Epub 2012 Mar 27.
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