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Signaling Pathway

KU-0063794

HY-50710

(KU 0063794; KU0063794)

KU-0063794

KU-0063794 Chemical Structure

KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively); no effect on PI3Ks.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $70 In-stock
50 mg $220 In-stock
100 mg $400 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
5 mg €49 In-stock
10 mg €69 In-stock
50 mg €216 In-stock
100 mg €392 In-stock
200 mg Get quote
500 mg Get quote

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Product name: KU-0063794
Cat. No.: HY-50710

KU-0063794 Data Sheet

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    Purity: 99.79%

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    DataSheet

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    COA

Related Compound Libraries

Biological Activity of KU-0063794

KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively); no effect on PI3Ks.
IC50 value: ~10 nM [1]
Target: mTORC1/C2
KU-0063794 displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. KU-0063794 suppresses cell growth and induces G1 cell cycle arrest in vitro.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 465.54 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C25H31N5O4
CAS No 938440-64-3
Solvent & Solubility

DMSO ≥10mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1480 mL 10.7402 mL 21.4804 mL
5 mM 0.4296 mL 2.1480 mL 4.2961 mL
10 mM 0.2148 mL 1.0740 mL 2.1480 mL

Clinical Information of KU-0063794

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
KU-0063794 Queen Mary University of London Metastatic renal cancer 28-FEB-13 31-DEC-15 Phase 2 15-NOV-13
AstraZeneca plc Advanced solid tumor 31-DEC-09 28-FEB-14 Phase 1 06-NOV-13
AstraZeneca plc Metastatic breast cancer 31-MAY-12 30-NOV-13 Phase 1 01-NOV-13

References on KU-0063794

Inhibitor Kit

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