1. Epigenetics
  2. Histone Methyltransferase

MI-3 (Synonyms: Menin-MLL inhibitor 3)

Cat. No.: HY-15223 Purity: 99.63%
Data Sheet SDS Handling Instructions

MI-3 is a Menin-MLL interaction inhibitor with IC50 value of 648 ± 25 nM.

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MI-3 Chemical Structure

MI-3 Chemical Structure

CAS No. : 1271738-59-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $143 In-stock
5 mg $130 In-stock
10 mg $210 In-stock
50 mg $700 In-stock
100 mg $900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MI-3 is a Menin-MLL interaction inhibitor with IC50 value of 648 ± 25 nM. IC50 value: 648 ± 25 nM [1] Target: Menin-MLL in vitro: The menin-MLL inhibitors very effectively blocked proliferation of MLL-AF9 and MLL-ENL transduced BMC, with GI50 values of about 5 μM for MI-2 and MI-3. MI-2 and MI-3 showed only a small effect on the cell growth of E2A-HLF transduced BMC (GI50 > 50 μM). MI-2 and MI-3 substantially and specifically reduce the immortalization potential of cells transformed with MLL fusion oncoproteins [1]. in vivo: MLL-AF9 transformed BMC that remained viable after 7 days of treatment with MI-2 and MI-3 showed substantial changes in morphology, indicative of monocytic differentiation, as evidenced by increased cell size, lower nuclear to cytoplasmic ratio and highly vacuolated cytoplasm. Consistent with the change in cell morphology, the expression of CD11b was substantially increased on MLL-AF9 transformed BMC after 7 days of treatment with MI-2 and MI-3 [1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.6628 mL 13.3138 mL 26.6276 mL
5 mM 0.5326 mL 2.6628 mL 5.3255 mL
10 mM 0.2663 mL 1.3314 mL 2.6628 mL
References
Molecular Weight

375.55

Formula

C₁₈H₂₅N₅S₂

CAS No.

1271738-59-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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MI-3
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