2. Metabolic Enzyme/Protease MAPK/ERK Pathway
  3. Endogenous Metabolite JNK p38 MAPK
  4. p-Cresyl sulfate potassium

p-Cresyl sulfate potassium  (Synonyms: p-Tolyl sulfate potassium)

Cat. No.: HY-111431A Purity: 99.86%
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p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.

For research use only. We do not sell to patients.

p-Cresyl sulfate potassium Chemical Structure

p-Cresyl sulfate potassium Chemical Structure

CAS No. : 91978-69-7

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of p-Cresyl sulfate potassium:

p-Cresyl sulfate potassium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE p-Cresyl sulfate potassium

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JNK1 JNK2 JNK3 JNK

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

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Description

p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity[1][2].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

p-Cresyl sulfate potassium (0.125 mM, 24 h) induces osteoblast dysfunction by activating JNK and p38 MAPK pathways[1].
p-Cresyl sulfate potassium (40 μg/mL, 30 min) inhibits adipogenesis and increases lipolysis of adipocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p-Cresyl sulfate potassium Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary osteoblastic cells
Concentration: 0.05, 0.125, 0.25, 0.5 mM
Incubation Time: 24 h
Result: Decreased cell viability in a dose-dependent manner.

Cell Proliferation Assay[1]

Cell Line: Primary osteoblastic cells
Concentration: 0.05, 0.125, 0.25, 0.5 mM
Incubation Time: 24 h
Result: Increased DNA fragmentation and decreased cell proliferation.

Western Blot Analysis[1]

Cell Line: Primary osteoblastic cells
Concentration: 0.125 mM
Incubation Time: 24 h
Result: Induced rapid and sustained phosphorylation of JNK.
In Vivo

p-Cresyl sulfate potassium (10 mg/kg intraperitoneal injection twice daily for 4 weeks) promotes insulin resistance associated with CKD in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CKD mice modrl[2]
Dosage: 10 mg/kg
Administration: i.p.
Result: Increased fasting plasma glucose concentration and plasma cholesterol levels.
Molecular Weight

226.29

Formula

C7H7KO4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(OC1=CC=C(C)C=C1)(O[K])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (552.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (441.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4191 mL 22.0955 mL 44.1911 mL
5 mM 0.8838 mL 4.4191 mL 8.8382 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (220.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

COA (250 KB) HNMR (241 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.4191 mL 22.0955 mL 44.1911 mL 110.4777 mL
5 mM 0.8838 mL 4.4191 mL 8.8382 mL 22.0955 mL
10 mM 0.4419 mL 2.2096 mL 4.4191 mL 11.0478 mL
15 mM 0.2946 mL 1.4730 mL 2.9461 mL 7.3652 mL
20 mM 0.2210 mL 1.1048 mL 2.2096 mL 5.5239 mL
25 mM 0.1768 mL 0.8838 mL 1.7676 mL 4.4191 mL
30 mM 0.1473 mL 0.7365 mL 1.4730 mL 3.6826 mL
40 mM 0.1105 mL 0.5524 mL 1.1048 mL 2.7619 mL
50 mM 0.0884 mL 0.4419 mL 0.8838 mL 2.2096 mL
60 mM 0.0737 mL 0.3683 mL 0.7365 mL 1.8413 mL
80 mM 0.0552 mL 0.2762 mL 0.5524 mL 1.3810 mL
100 mM 0.0442 mL 0.2210 mL 0.4419 mL 1.1048 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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p-Cresyl sulfate potassium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Cresyl sulfate91978-69-7p-Tolyl sulfateEndogenous MetaboliteJNKp38 MAPKc-Jun N-terminal kinasePrimary osteoblastic cellsCKDUremic toxinInhibitorinhibitorinhibit

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