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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

PF-04691502

HY-15177

(PF 04691502; PF04691502)

PF-04691502

PF-04691502 Chemical Structure

PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $120 In-stock
50 mg $440 In-stock
100 mg $780 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €86 In-stock
5 mg €78 In-stock
10 mg €118 In-stock
50 mg €431 In-stock
100 mg €764 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: PF-04691502
Cat. No.: HY-15177

PF-04691502 Data Sheet

  • View current batch:

    Purity: 99.72%

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    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of PF-04691502

PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK.
IC50 value:  1.8 nM/2.1 nM/1.6 nM/1.9 nM(PI3Kα/β/δ/γ); 16 nM(mTOR)
Target: PI3K/mTOR
PF-04691502 is an ATP-competitive PI3K/mTOR dual inhibitor with IC50 of 32 nM. PF-04691502 is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PF-04691502 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. PF-04691502 is currently in Phase II clinical trials in patients with recurrent endometrial cancer and Breast Cancer. A Phase II clinical trials in patients with solid tumors has been completed.

Chemical Information

M.Wt 425.48 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C22H27N5O4
CAS No 1013101-36-4
Solvent & Solubility

DMSO > 60 mg/mL Ethanol > 60 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.3503 mL 11.7514 mL 23.5029 mL
5 mM 0.4701 mL 2.3503 mL 4.7006 mL
10 mM 0.2350 mL 1.1751 mL 2.3503 mL

Clinical Information of PF-04691502

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
PF-04691502 Pfizer Inc Metastatic breast cancer 31-JAN-13 30-APR-15 Phase 2 11-SEP-13
Pfizer Inc Advanced solid tumor 31-DEC-09 30-APR-12 Phase 1 31-MAY-12
Pfizer Inc Endometrioid carcinoma 01-JAN-12 31-MAY-14 Phase 2 28-NOV-13
Pfizer Inc Breast tumor 31-MAR-12 31-DEC-12 Phase 2 26-DEC-12
Pfizer Inc Advanced solid tumor 31-OCT-11 30-NOV-14 Phase 1 06-NOV-13

References on PF-04691502

Inhibitor Kit

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