Fiacitabine (Synonyms: NSC 382097; FIAC; FOAC)

Cat. No.: HY-50735 Purity: 98.83%: FAQs
Data Sheet SDS COA Handling Instructions

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Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.

For research use only. We do not sell to patients.

Fiacitabine Chemical Structure

CAS No. : 69123-90-6

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 462	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 462	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
References
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Description

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. IC50 value: 2.5/12.6 nM (HSV1/2) [2] Target: HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay. FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of virus-specified thymidine kinase [2].

IC₅₀ & Target

HSV-1

HSV-2

Clinical Trial

Molecular Weight

371.10

Formula

C₉H₁₁FIN₃O₄

CAS No.

69123-90-6

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N(C=C2I)C(N=C2N)=O)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 37 mg/mL (99.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6947 mL	13.4735 mL	26.9469 mL
5 mM	0.5389 mL	2.6947 mL	5.3894 mL
10 mM	0.2695 mL	1.3473 mL	2.6947 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.83%

Select Batch:

Data Sheet (275 KB) SDS (0 KB)

COA (252 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

References

[1]. Allaudeen HS, et al. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine. J Biol Chem. 1982 Oct 25;257(20):11879-82. [Content Brief]

[2]. Lopez C, et al. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17(5):803-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6947 mL	13.4735 mL	26.9469 mL	67.3673 mL
	5 mM	0.5389 mL	2.6947 mL	5.3894 mL	13.4735 mL
	10 mM	0.2695 mL	1.3473 mL	2.6947 mL	6.7367 mL
	15 mM	0.1796 mL	0.8982 mL	1.7965 mL	4.4912 mL
	20 mM	0.1347 mL	0.6737 mL	1.3473 mL	3.3684 mL
	25 mM	0.1078 mL	0.5389 mL	1.0779 mL	2.6947 mL
	30 mM	0.0898 mL	0.4491 mL	0.8982 mL	2.2456 mL
	40 mM	0.0674 mL	0.3368 mL	0.6737 mL	1.6842 mL
	50 mM	0.0539 mL	0.2695 mL	0.5389 mL	1.3473 mL
	60 mM	0.0449 mL	0.2246 mL	0.4491 mL	1.1228 mL
	80 mM	0.0337 mL	0.1684 mL	0.3368 mL	0.8421 mL

Fiacitabine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fiacitabine69123-90-6NSC 382097 FIAC FOACNSC382097NSC-382097HSVHerpes simplex virusInhibitorinhibitorinhibit

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