Zaltidine (Synonyms: CP-57361)

Cat. No.: HY-15541 Purity: 99.49%: FAQs
Data Sheet SDS COA Handling Instructions

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Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action.

For research use only. We do not sell to patients.

Zaltidine Chemical Structure

CAS No. : 85604-00-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 317	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 317	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 288	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1440	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Purity & Documentation
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Description

Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action. IC50 Value: Target: H2 receptor in vitro: in vivo: In eight healthy male volunteers single oral doses of 5 mg, 25 mg and 100 mg produced dose-related inhibition of basal and pentagastrin-stimulated acid output (M.A.O.) with an estimated ID50 of 40 mg for the latter. In eight subjects with duodenal ulceration single 100 mg and 200 mg doses produced 85% and 97% inhibition of M.A.O. at peak (3 h post-dose) and 20% and 23% inhibition at 24 h, respectively; inhibition of basal acid output was 97% at 3 h and 50% at 24 h with both doses [1]. One hundred and thirty-five patients were randomly allocated to 4 weeks' treatment with either 150 mg zaltidine once daily or placebo. Fifty-nine were treated for a full 4 weeks with zaltidine before the trial was stopped. Healing rates after 4 weeks of zaltidine and placebo were 86% and 19%, respectively (p less than 0.001) [2].

Molecular Weight

222.27

Formula

C₈H₁₀N₆S

CAS No.

85604-00-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

NC(NC1=NC(C2=CN=C(C)N2)=CS1)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 7.69 mg/mL (34.60 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4990 mL	22.4952 mL	44.9903 mL
5 mM	0.8998 mL	4.4990 mL	8.9981 mL
10 mM	0.4499 mL	2.2495 mL	4.4990 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.49%

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Data Sheet (272 KB) SDS (0 KB)

COA (246 KB) HNMR (281 KB) LCMS (263 KB)

Handling Instructions (2659 KB)

References

[1]. Laferla G, Buchanan N, Hearns J, The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22(4):395-9. [Content Brief]

[2]. Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23(6):655-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.4990 mL	22.4952 mL	44.9903 mL	112.4758 mL
	5 mM	0.8998 mL	4.4990 mL	8.9981 mL	22.4952 mL
	10 mM	0.4499 mL	2.2495 mL	4.4990 mL	11.2476 mL
	15 mM	0.2999 mL	1.4997 mL	2.9994 mL	7.4984 mL
	20 mM	0.2250 mL	1.1248 mL	2.2495 mL	5.6238 mL
	25 mM	0.1800 mL	0.8998 mL	1.7996 mL	4.4990 mL
	30 mM	0.1500 mL	0.7498 mL	1.4997 mL	3.7492 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Zaltidine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zaltidine85604-00-8CP-57361CP57361CP 57361Histamine ReceptorInhibitorinhibitorinhibit

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