4-Chlorophenylguanidine hydrochloride

Cat. No.: HY-100939 Purity: 99.07%: FAQs
Data Sheet SDS COA Handling Instructions

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4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo.

For research use only. We do not sell to patients.

4-Chlorophenylguanidine hydrochloride Chemical Structure

CAS No. : 14279-91-5

Size	Price	Stock	Quantity
100 mg	USD 626	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

206.07

Formula

C₇H₉Cl₂N₃

CAS No.

14279-91-5

Appearance

Solid

Color

Off-white to gray

SMILES

NC(NC1=CC=C(Cl)C=C1)=N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (606.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8527 mL	24.2636 mL	48.5272 mL
5 mM	0.9705 mL	4.8527 mL	9.7054 mL
10 mM	0.4853 mL	2.4264 mL	4.8527 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.07%

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Data Sheet (267 KB) SDS (0 KB)

COA (246 KB) HNMR (234 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Amruta S Agharkar, et al. 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J Pharmacol Sci. 2017 Mar;133(3):184-186. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8527 mL	24.2636 mL	48.5272 mL	121.3180 mL
	5 mM	0.9705 mL	4.8527 mL	9.7054 mL	24.2636 mL
	10 mM	0.4853 mL	2.4264 mL	4.8527 mL	12.1318 mL
	15 mM	0.3235 mL	1.6176 mL	3.2351 mL	8.0879 mL
	20 mM	0.2426 mL	1.2132 mL	2.4264 mL	6.0659 mL
	25 mM	0.1941 mL	0.9705 mL	1.9411 mL	4.8527 mL
	30 mM	0.1618 mL	0.8088 mL	1.6176 mL	4.0439 mL
	40 mM	0.1213 mL	0.6066 mL	1.2132 mL	3.0329 mL
	50 mM	0.0971 mL	0.4853 mL	0.9705 mL	2.4264 mL
	60 mM	0.0809 mL	0.4044 mL	0.8088 mL	2.0220 mL
	80 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5165 mL
	100 mM	0.0485 mL	0.2426 mL	0.4853 mL	1.2132 mL