Afegostat D-Tartrate (Synonyms: D-Isofagomine D-Tartrate; Isofagomine D-Tartrate)

Cat. No.: HY-14829E: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

For research use only. We do not sell to patients.

Afegostat D-Tartrate Chemical Structure

CAS No. : 957230-65-8

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1 mg	USD 190	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
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Description

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity^[1].

IC₅₀ & Target

GCase^[1]

In Vivo

Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

297.26

Formula

C₁₀H₁₉NO₉

CAS No.

957230-65-8

Appearance

Solid

Color

Yellow to brown

SMILES

OC[C@@H]1[C@H]([C@@H](CNC1)O)O.OC([C@@H](O)[C@H](O)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (168.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3641 mL	16.8203 mL	33.6406 mL
5 mM	0.6728 mL	3.3641 mL	6.7281 mL
10 mM	0.3364 mL	1.6820 mL	3.3641 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (257 KB) HNMR (196 KB) MS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.3641 mL	16.8203 mL	33.6406 mL	84.1015 mL
	5 mM	0.6728 mL	3.3641 mL	6.7281 mL	16.8203 mL
	10 mM	0.3364 mL	1.6820 mL	3.3641 mL	8.4101 mL
	15 mM	0.2243 mL	1.1214 mL	2.2427 mL	5.6068 mL
	20 mM	0.1682 mL	0.8410 mL	1.6820 mL	4.2051 mL
	25 mM	0.1346 mL	0.6728 mL	1.3456 mL	3.3641 mL
	30 mM	0.1121 mL	0.5607 mL	1.1214 mL	2.8034 mL
	40 mM	0.0841 mL	0.4205 mL	0.8410 mL	2.1025 mL
	50 mM	0.0673 mL	0.3364 mL	0.6728 mL	1.6820 mL
	60 mM	0.0561 mL	0.2803 mL	0.5607 mL	1.4017 mL
	80 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0513 mL
	100 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8410 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Afegostat D-Tartrate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Afegostat957230-65-8D-IsofagomineIsofagomineGlucosidaseInhibitorinhibitorinhibit

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