2. Anti-infection
  3. Bacterial
  4. BRD7116

BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.

For research use only. We do not sell to patients.

BRD7116 Chemical Structure

BRD7116 Chemical Structure

CAS No. : 329059-55-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
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10 mg USD 90 In-stock
50 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

BRD7116 Related Antibodies

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Description

BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. IC50 value: 200 nM (EC50, for LSCe cells) Target: DNA gyrase BRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. [1] BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs.

Molecular Weight

496.66

Formula

C28H36N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 48 mg/mL (96.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0134 mL 10.0672 mL 20.1345 mL
5 mM 0.4027 mL 2.0134 mL 4.0269 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0134 mL 10.0672 mL 20.1345 mL 50.3362 mL
5 mM 0.4027 mL 2.0134 mL 4.0269 mL 10.0672 mL
10 mM 0.2013 mL 1.0067 mL 2.0134 mL 5.0336 mL
15 mM 0.1342 mL 0.6711 mL 1.3423 mL 3.3557 mL
20 mM 0.1007 mL 0.5034 mL 1.0067 mL 2.5168 mL
25 mM 0.0805 mL 0.4027 mL 0.8054 mL 2.0134 mL
30 mM 0.0671 mL 0.3356 mL 0.6711 mL 1.6779 mL
40 mM 0.0503 mL 0.2517 mL 0.5034 mL 1.2584 mL
50 mM 0.0403 mL 0.2013 mL 0.4027 mL 1.0067 mL
60 mM 0.0336 mL 0.1678 mL 0.3356 mL 0.8389 mL
80 mM 0.0252 mL 0.1258 mL 0.2517 mL 0.6292 mL
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BRD7116 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD7116329059-55-4BRD 7116BRD-7116BacterialInhibitorinhibitorinhibit

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