2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Membrane Transporter/Ion Channel
  3. DNA/RNA Synthesis TGF-beta/Smad Proton Pump
  4. Chebulinic acid

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

For research use only. We do not sell to patients.

Chebulinic acid Chemical Structure

Chebulinic acid Chemical Structure

CAS No. : 18942-26-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 368 In-stock
Solution
10 mM * 1 mL in DMSO USD 368 In-stock
Solid
1 mg USD 90 In-stock
5 mg USD 220 In-stock
10 mg USD 350 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Chebulinic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chebulinic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

IC50 & Target

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]
In Vitro

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chebulinic acid Related Antibodies
Molecular Weight

956.68

Formula

C41H32O27
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C[C@H](C(O[C@@]([C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[C@@]1([H])OC5=O)=O)[C@@]([C@H]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (104.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0453 mL 5.2264 mL 10.4528 mL
5 mM 0.2091 mL 1.0453 mL 2.0906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.42%

COA (269 KB) HNMR (236 KB) LCMS (84 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0453 mL 5.2264 mL 10.4528 mL 26.1320 mL
5 mM 0.2091 mL 1.0453 mL 2.0906 mL 5.2264 mL
10 mM 0.1045 mL 0.5226 mL 1.0453 mL 2.6132 mL
15 mM 0.0697 mL 0.3484 mL 0.6969 mL 1.7421 mL
20 mM 0.0523 mL 0.2613 mL 0.5226 mL 1.3066 mL
25 mM 0.0418 mL 0.2091 mL 0.4181 mL 1.0453 mL
30 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8711 mL
40 mM 0.0261 mL 0.1307 mL 0.2613 mL 0.6533 mL
50 mM 0.0209 mL 0.1045 mL 0.2091 mL 0.5226 mL
60 mM 0.0174 mL 0.0871 mL 0.1742 mL 0.4355 mL
80 mM 0.0131 mL 0.0653 mL 0.1307 mL 0.3267 mL
100 mM 0.0105 mL 0.0523 mL 0.1045 mL 0.2613 mL
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Chebulinic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chebulinic acid18942-26-2DNA/RNA SynthesisTGF-beta/SmadProton PumpTransforming growth factor betaInhibitorinhibitorinhibit

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