2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Coluracetam

Coluracetam  (Synonyms: MKC-231)

Cat. No.: HY-17553 Purity: 99.87%
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Coluracetam(MKC-231) is a new choline uptake enhancer.

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Coluracetam Chemical Structure

Coluracetam Chemical Structure

CAS No. : 135463-81-9

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10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

Coluracetam Related Antibodies

Top Publications Citing Use of Products

    Coluracetam purchased from MedChemExpress. Usage Cited in: J Pain Res. 2018 Sep 21;11:1971-1982.  [Abstract]

    Immunoblots for CHT1 in the colon of WAS and WAS-MKC-231-treated rats reveal that the ratios of CHT1 to β-actin expression in WAS rats are considerably increased after 10 consecutive days of MKC-231 treatment.

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    Description

    Coluracetam(MKC-231) is a new choline uptake enhancer. IC50 value: Target: in vitro: MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding [1]. in vivo: Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested [2].

    Molecular Weight

    341.40

    Formula

    C19H23N3O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC1=C2C(OC(C)=C2C)=NC3=C1CCCC3)CN4C(CCC4)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 20 mg/mL (58.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 0.4 mg/mL (1.17 mM; Need ultrasonic and warming)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9291 mL 14.6456 mL 29.2912 mL
    5 mM 0.5858 mL 2.9291 mL 5.8582 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.9291 mL 14.6456 mL 29.2912 mL 73.2279 mL
    DMSO 5 mM 0.5858 mL 2.9291 mL 5.8582 mL 14.6456 mL
    10 mM 0.2929 mL 1.4646 mL 2.9291 mL 7.3228 mL
    15 mM 0.1953 mL 0.9764 mL 1.9527 mL 4.8819 mL
    20 mM 0.1465 mL 0.7323 mL 1.4646 mL 3.6614 mL
    25 mM 0.1172 mL 0.5858 mL 1.1716 mL 2.9291 mL
    30 mM 0.0976 mL 0.4882 mL 0.9764 mL 2.4409 mL
    40 mM 0.0732 mL 0.3661 mL 0.7323 mL 1.8307 mL
    50 mM 0.0586 mL 0.2929 mL 0.5858 mL 1.4646 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Coluracetam135463-81-9MKC-231MKC231MKC 231iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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