2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Dapiprazole hydrochloride

Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis.

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Dapiprazole hydrochloride Chemical Structure

Dapiprazole hydrochloride Chemical Structure

CAS No. : 72822-13-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 39 In-stock
Solution
10 mM * 1 mL in DMSO USD 39 In-stock
Solid
5 mg USD 35 In-stock
10 mg USD 55 In-stock
25 mg USD 110 In-stock
50 mg USD 168 In-stock
100 mg USD 250 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Dapiprazole hydrochloride:

Dapiprazole hydrochloride Related Antibodies

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis[1][2][3].

IC50 & Target

α1-adrenergic receptor

 

In Vivo

Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model[1]
Dosage: 5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration: Intraperitoneal injection or intracerebroventricular administration, once
Result: Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
Molecular Weight

361.91

Formula

C19H28ClN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (276.31 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (34.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7631 mL 13.8156 mL 27.6312 mL
5 mM 0.5526 mL 2.7631 mL 5.5262 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (138.16 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.7631 mL 13.8156 mL 27.6312 mL 69.0779 mL
5 mM 0.5526 mL 2.7631 mL 5.5262 mL 13.8156 mL
10 mM 0.2763 mL 1.3816 mL 2.7631 mL 6.9078 mL
15 mM 0.1842 mL 0.9210 mL 1.8421 mL 4.6052 mL
20 mM 0.1382 mL 0.6908 mL 1.3816 mL 3.4539 mL
25 mM 0.1105 mL 0.5526 mL 1.1052 mL 2.7631 mL
30 mM 0.0921 mL 0.4605 mL 0.9210 mL 2.3026 mL
H2O 40 mM 0.0691 mL 0.3454 mL 0.6908 mL 1.7269 mL
50 mM 0.0553 mL 0.2763 mL 0.5526 mL 1.3816 mL
60 mM 0.0461 mL 0.2303 mL 0.4605 mL 1.1513 mL
80 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8635 mL
100 mM 0.0276 mL 0.1382 mL 0.2763 mL 0.6908 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dapiprazole hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dapiprazole72822-13-0Adrenergic ReceptorBeta Receptoropioid withdrawalmydriasisInhibitorinhibitorinhibit

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